2018
DOI: 10.3892/ol.2018.9336
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Identification of ceRNA network based on a RNA‑seq shows prognostic lncRNA biomarkers in human lung adenocarcinoma

Abstract: Previous studies have emphasized the significant functions of long non-coding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) in tumor biology. However, the functions of certain cancer lncRNAs in the lncRNA-related ceRNA network in lung adenocarcinoma (LUAD) are unknown. A systematic and integrative survey of RNA-seq data from The Cancer Genome Atlas (TCGA) was performed to identify candidate lncRNAs for the prognosis of LUAD. In total, 20,502 genes that contain 181 lncRNAs were evaluated in a cohort of 5… Show more

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Cited by 29 publications
(29 citation statements)
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“…Cell cycle dysfunction in LUAD was consistent with our results. A recent study demonstrated that cell cycle-related genes, such as E2F1 (Chen et al, 2019), were enriched during the regulation of the cell cycle progression (Li et al, 2018;Qi et al, 2019). In the present study, we found that lncRNA RAET1K could promote cell cycle dysfunction, providing insight into the crosstalk regulatory mechanism between lncRNAs and coding genes.…”
Section: Discussionsupporting
confidence: 63%
“…Cell cycle dysfunction in LUAD was consistent with our results. A recent study demonstrated that cell cycle-related genes, such as E2F1 (Chen et al, 2019), were enriched during the regulation of the cell cycle progression (Li et al, 2018;Qi et al, 2019). In the present study, we found that lncRNA RAET1K could promote cell cycle dysfunction, providing insight into the crosstalk regulatory mechanism between lncRNAs and coding genes.…”
Section: Discussionsupporting
confidence: 63%
“…22 ceRNAs in patients with LUAD have been widely researched in recent years using TCGA data. [23][24][25] However, ceRNA networks have not been previously investigated in the context of LUAD metastasis. Therefore, our objective was to obtain an in-depth understanding of the ceRNA network in cancer metastasis, using metastatic and non-metastatic tumour data from the TCGA database.…”
Section: Mir-mentioning
confidence: 99%
“…Only microRNAs recorded with first 10 and last 10 FC values were selected for subsequent analysis (Li et al 2018;Shao & Li 2019). Because these biggest expression changed miRNA may have real major function in HCC.…”
Section: Data Preprocessing and Differential Gene Selectionmentioning
confidence: 99%