Identification of characteristic compounds of moderate volatility in breast cancer cell lines

Tanaka, Mitsuru; Chung, Habong; Oeki, Masataka; Shen, Weilin; Goda, Asuka; Tahara, Yusuke; Onodera, Takeshi; Sanematsu, Keisuke; Rikitake, Tomotsugu; Oki, Eiji; Ninomiya, Yuzo; Kurebayashi, Rintaro; Sonoda, Hideto; Maehara, Yoshihiko; Toko, Kiyoshi; Matsui, Toshiro

doi:10.1371/journal.pone.0235442

Cited by 10 publications

(8 citation statements)

References 37 publications

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“…En los diferentes estudios se ha reconocido que las células transformadas inducen una reprogramación metabólica en la búsqueda y generación de energía que derivan de la glucólisis aeróbica y la oxidación de ácidos grasos de cadena media y larga, lo cual implica que se aleje de la vía de la fosforilación oxidativa mitocondrial o efecto Warburg 31 . Esto se explica mediante la exposición a microambientes con estrés oxidativo 18 .…”

Section: Discussionunclassified

“…De los análisis de COV provenientes de líneas celulares, se identificaron cinco estudios basados en la experimentación in vitro de líneas celulares y biopsia de tejido mamario maligno. En cuatro estudios se empleó la línea celular MCF-7 [16][17][18][19] , en dos estudios utilizaron las células MDA-MB-231 [17][18][19] y en un estudio utilizaron biopsias de tejido mamario maligno 20 . Como resultado, se obtuvieron 72 COV agrupados en su mayoría en alcoholes, cetonas, alcanos y aldehídos (Fig.…”

Section: Evidencia In Vitro De Que Las Líneas Celulares «Exhalan» Covunclassified

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Compuestos orgánicos volátiles exhalados: ¿eficaces para detectar cáncer de mama?

Alamilla-Valenzuela¹,

Erazo-Lema²,

Hernández-Hernández³

et al. 2023

GAMO

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Introducción: El cáncer de mama (CaMa) es el tipo de cáncer con una alta tasa de mortalidad y su diagnóstico oportuno, permitiría una mayor probabilidad de sobrevivencia. Actualmente hay diversos procedimientos para su detección, sin embargo, una posible alternativa no invasiva mediante la detección de compuestos orgánicos volátiles (COV) en el aliento (exhalómica) de las pacientes se está explorando. Métodos: Se realizó una revisión sistemática (hasta junio de 2022) de publicaciones sobre la detección mediante cromatografía de gases de COV en el aliento de mujeres con mama sana, con lesiones benignas o invasoras y en líneas celulares, para buscar potenciales oncometabolitos. Resultados: Existe una gran heterogeneidad de COV (principalmente alcanos) en las pacientes analizadas, además de diferencias entre las distintas poblaciones. Discusión: Aun cuando hay detección de COV exhalados, es necesario un mayor número de estudios. De manera interesante, un grupo de COV son compartidos con otros tipos de cáncer. Conclusiones: Al momento, no se conoce el perfil de COV exhalados asociados con certeza al paciente de CaMa.

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Section: Discussionunclassified

Section: Evidencia In Vitro De Que Las Líneas Celulares «Exhalan» Covunclassified

Compuestos orgánicos volátiles exhalados: ¿eficaces para detectar cáncer de mama?

Alamilla-Valenzuela¹,

Erazo-Lema²,

Hernández-Hernández³

et al. 2023

GAMO

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“…In different studies, it has been recognized that transformed cells induce metabolic reprogramming in the search for and generation of energy deriving from aerobic glycolysis and medium and long chain fatty acids oxidation, which implies that it moves away from the pathway of mitochondrial oxidative phosphorylation or Warburg effect 31 . This is explained by exposure to microenvironments with oxidative stress 18 .…”

Section: Discussionmentioning

confidence: 99%

“…As for VOC analyses using cell lines, five studies were identified based on in vitro experimentation on cell lines and malignant breast tissue biopsy. Four studies used the MCF-7 cell line [16][17][18][19] , two studies used MDA-MB-231 cells [17][18][19] , and one study used malignant breast tissue biopsies 20 . As a result, 72 VOCs, mostly grouped into alcohols, ketones, alkanes, and aldehydes, were obtained (Fig.…”

Section: In Vitro Evidence That Cell Lines "Exhale" Vocsmentioning

confidence: 99%

Exhaled volatile organic compounds: effective in detecting breast cancer?

Alamilla-Valenzuela¹,

Erazo-Lema²,

Hernández-Hernández³

et al. 2023

GAMO

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Background: Breast cancer (BrCa) presents a highest mortality rate, and its early diagnosis could improve the survival of the patient. At present, there are leading tests used for BrCa detection, but a novel alternative, non-invasive test, such as breath analysis (exhalomic) of volatile organic compounds (VOCs), are being taken into consideration. Methods: A systematic review (until June 2022) about VOC detection from breath using gas chromatography was performed. The goal was to identify probable oncometabolites in the gas sample from healthy breast tissue women, benign, or malignant lesions, and including cultured cell lines. Results: There are a complex heterogeneity of exhaled VOC mainly alkanes in the analyzed samples, and between the different populations. Discussion: Even when exhaled VOC is detected, some more works should be performed to have conclusions. Interestingly, some VOC is shared with other cancer types. Conclusions: Nowadays, there is no specific BrCa VOC-profile associated for BrCa or benign lesions diagnosis.

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“…Identification of characteristic compounds of moderate volatility in breast cancer cell lines Tanaka et al 68 Breast cancer…”

Section: Culture Mediamentioning

confidence: 99%

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review

et al. 2022

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Introduction: An early diagnosis is crucial in reducing mortality among people who have breast cancer (BC). There is a shortfall of characteristic early clinical symptoms in BC patients, highlighting the importance of investigating new methods for its early detection. A promising novel approach is the analysis of volatile organic compounds (VOCs) produced and emitted through the metabolism of cancer cells. Methods: The purpose of this systematic review is to outline the published research regarding BC-associated VOCs. For this, headspace analysis of VOCs was explored in patient-derived body fluids, animal model-derived fluids, and BC cell lines to identify BC-specific VOCs. A systematic search in PubMed and Web of Science databases was conducted according to the PRISMA guidelines. Results: Thirty-two studies met the criteria for inclusion in this review. Results highlight that VOC analysis can be promising as a potential novel screening tool. However, results of in vivo, in vitro and case-control studies have delivered inconsistent results leading to a lack of inter-matrix consensus between different VOC sampling methods. Discussion: Discrepant VOC results among BC studies have been obtained, highly due to methodological discrepancies. Therefore, methodological issues leading to disparities have been reviewed and recommendations have been made on the standardisation of VOC collection and analysis methods for BC screening, thereby improving future VOC clinical validation studies.

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Identification of characteristic compounds of moderate volatility in breast cancer cell lines

Cited by 10 publications

References 37 publications

Compuestos orgánicos volátiles exhalados: ¿eficaces para detectar cáncer de mama?

Compuestos orgánicos volátiles exhalados: ¿eficaces para detectar cáncer de mama?

Exhaled volatile organic compounds: effective in detecting breast cancer?

Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review

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