Identification of chemical compounds

Milman, Boris L.

doi:10.1016/j.trac.2005.03.013

Cited by 74 publications

(38 citation statements)

References 127 publications

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“…Furthermore, the chromatographic resolution shown for these water samples was poor, rendering library identification of specific compounds problematic (Budde, 2001). It has been suggested that matching spectra from a transferable reference database (EI spectra) is less reliable than matching the retention time of a known standard (Milman, 2005) and that matching factors ''are not to be used in a quantitative way'' (Stein, 1994).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the hypothesis that Balkan endemic nephropathy is caused by drinking water exposure to contaminants leaching from Pliocene coal deposits

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McElmurry

Long

et al. 2006

J Expo Sci Environ Epidemiol

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Balkan endemic nephropathy (BEN) is a kidney disease that has been reported in only certain rural villages in Serbia, Bulgaria, Romania, Croatia and Bosnia. The cause of BEN remains a mystery, but researchers seem to agree that exposure to one or more environmental agents is at least partially responsible. The Pliocene lignite hypothesis suggests the disease is due to long-term exposure to polycyclic aromatic hydrocarbons (PAHs) or other toxic organic compounds that have leached into drinking water supplies from low-rank coals. Although this hypothesis has been promoted by some researchers, efforts to substantiate it have been inconclusive due to limitations in sample size and methodology. The present study was designed to further examine this hypothesis by analyzing PAHs, which were implicated in the original hypothesis, in a larger number of water samples from endemic and nonendemic villages in Bulgaria and for other chemical differences between the villages. Results show that levels of all PAHs were low, with none exceeding the drinking water standard for benzo-[a]-pyrene, the most toxic PAH, and the only one for which a maximum contaminant level (MCL) has been set for drinking water. Comparison of additional unidentified chromatographic peaks from high-pressure liquid chromatography (HPLC) technique designed to detect dissolved organic compounds (DOCs) that leach from coal failed to show higher levels in BEN villages. This study finds no basis to connect PAHs or other unknown DOCs to the etiology of BEN, and suggests that the evidence in support of the Pliocene lignite hypothesis is limited to the spatial association originally proposed.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the hypothesis that Balkan endemic nephropathy is caused by drinking water exposure to contaminants leaching from Pliocene coal deposits

Voice

McElmurry

Long

et al. 2006

J Expo Sci Environ Epidemiol

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show abstract

“…In case where too many structures are proposed for the potential empirical formulas, we successfully reduced the number by utilizing the large NIST-EI database with its constrains functionality, despite the well known dissimilarity between ESI/MS/MS and EI/MS spectra [23].…”

Section: Introductionmentioning

confidence: 99%

Interpretation of ESI(+)-MS-MS spectra—Towards the identification of “unknowns”

Weissberg

Dagan

2011

International Journal of Mass Spectrometry

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“…Since the outcome of a toxicological analysis can have pivotal judicial, social, personal and/or economic consequences, approaches in this area need to be scientifically sound and legally defensible [1]. Thus, identification of pharmacologically active, toxic, and/or illicit drugs in samples like seizures, counterfeits, and biological specimens should be based on the comparison of results from a number of tests with reference data on all substances that may come into consideration [2]. Gas chromatography hyphenated to mass spectrometry (GC/MS) is regarded as golden standard for most types of general unknown screening (GUS) analyses [3].…”

Section: Introductionmentioning

confidence: 99%