Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes

Higuchi, Chigusa; Nakatsuka, Atsuko; Eguchi, Jun; Teshigawara, Sanae; Kanzaki, Motoko; Katayama, Akihiro; Yamaguchi, Satoshi; Takahashi, Naoto; Murakami, Kazutoshi; Ogawa, Daisuke; Sasaki, Shuhei; Makino, Hírofumi; Wada, Jun

doi:10.1016/j.metabol.2014.12.003

Cited by 151 publications

(115 citation statements)

References 28 publications

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“…Depletion of miR-375 causes diabetic phenotype by reducing the β-cell mass and insulin levels. It has been identified as a biomarker for T2DM in serum collected from Chinese and Japanese subjects [75,84,85].…”

Section: Mir-375mentioning

confidence: 99%

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MIRNAS: Early Prognostic Biomarkers for Type 2 Diabetes Mellitus?

et al. 2015

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Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and is associated with peripheral insulin resistance. The currently used therapies aim to delay progression of T2DM. Their efficacy could drastically be improved if implemented at earlier stages. Classical diagnostic markers (blood glucose and HbA1C) are generally detected once metabolic imbalance has already set in. Therefore, development of biomarkers for early diagnosis would help identify individuals at risk for developing T2DM. Along with genetic predisposition, epigenetics also plays a major role in T2DM development. In this review, we discuss the potential role of early diagnostic markers such as circulating miRNAs, studies done so far and challenges to be considered while taking into account the novel role of miRNAs as prognostic biomarkers.

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Section: Mir-375mentioning

confidence: 99%

“…TCF2 has been identified as the target for miR-802 [109]. miR-802 has been shown to be upregulated in serum samples collected from Japanese population [84].…”

Section: Mir-802mentioning

confidence: 99%

MIRNAS: Early Prognostic Biomarkers for Type 2 Diabetes Mellitus?

et al. 2015

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“…miRs are evolutionarily conserved, small single-stranded molecules (20-24 nucleotides), that have been postulated to regulate the expression of approximately 50% of the genes in a cell at the post-transcriptional level [62,63]. In contrast to other endogenous small RNAs, miRNAs derive from transcripts forming distinctive hairpin structures [64].…”

Section: Micrornas and Their Biological Rolesmentioning

confidence: 99%

Non-coding RNA-mediated epigenetic regulation of liver fibrosis

et al. 2015

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“…miRNA modulate various biological functions, such as cell proliferation, growth, apoptosis, and signal transduction (Chen et al, 2015;Femminella et al, 2015;Higuchi et al, 2015;Wang et al, 2015). Previous studies have also reported that miRNA-146a mediates cellular growth and proliferation in various cells (Alexandrov et al, 2014;Xie et al, 2014;Gu et al, 2015;Hill et al, 2015;Tang et al, 2015;Zhou et al, 2015), however, the role of miRNA-146a in coronary heart disease remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-κB pathway

Wu¹,

Liu²,

Wang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to investigate the role of miRNA146a in modulating the function of vascular smooth muscle cells in a rat model of coronary heart disease. Vascular smooth muscle cells were isolated and cultured from the rat coronary heart disease model and normal rats (controls). miRNA-146a levels were measured in vascular smooth muscle cells obtained from rats with coronary heart disease and control rats. The proliferation, growth, apoptosis, and activation of the NF-κB pathway in the vascular smooth muscle cells were detected using the MTT assay and flow cytometry, respectively. The role of the NF-κB pathway in modulating the apoptosis of vascular smooth muscle cells was investigated by measuring the reactivity of the cells to an NF-κB pathway inhibitor (TPCA-1). Vascular smooth muscle cells from the disease model exhibited higher levels of miRNA-146a than that by the normal controls (P = 0.0024). The vascular smooth muscle cells obtained from rats with Z.W. Wu et al. 18704©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18703-18712 (2015) coronary heart disease showed decreased proliferation and growth and increased apoptosis. miRNA-146a overexpression elevated the rate of cell apoptosis. The NF-κB pathway was activated in vascular smooth muscle cells obtained from rats with coronary heart disease. Inhibition of the NF-κB pathway significantly decreased the rate of vascular smooth muscle cell apoptosis in coronary heart disease rats (P = 0.0038). In conclusion, miRNA146a was found to induce vascular smooth muscle cell apoptosis in rats with coronary heart disease via the activation of the NF-κB signal pathway.

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Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes

Cited by 151 publications

References 28 publications

MIRNAS: Early Prognostic Biomarkers for Type 2 Diabetes Mellitus?

MIRNAS: Early Prognostic Biomarkers for Type 2 Diabetes Mellitus?

Non-coding RNA-mediated epigenetic regulation of liver fibrosis

miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-κB pathway

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