Identification of Clinical and Laboratory Variables Associated with Cardiotoxicity Events Due to Doxorubicin in Breast Cancer Patients: A 1-Year Follow-Up Study

Simões, Ricardo; Silva, Luciana Maria; Oliveira, Angélica Navarro de; Alves, Michelle Teodoro; Pestana, Rodrigo Mendonça Cardoso; Souza, Isabella D P de; Oliveira, Heloísa Helena Marques; Soares, Cintia Esteves; Sabino, Adriano de Paula; Gomes, Karina Braga

doi:10.1007/s12012-020-09600-7

Cited by 8 publications

(19 citation statements)

References 36 publications

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“…In a previous publication by our group [17], the evaluation over time, the hematimetric indices -Hb, Htc, Leuc, and Plaq, showed a statistically signi cant difference, which suggests that doxorubicin is capable of generating systemic alterations that modify the circulating levels of these biomarkers.…”

Section: Discussionmentioning

confidence: 81%

“…In the analysis of each independent variable, it is found in the literature that cTnI is a protein predominantly present in the myocardium, and plasma concentration is considered the gold standard in the diagnosis and prognosis of myocardial injury. Indeed, is usually increased after high doses of chemotherapy, being a recognized independent biomarker of cardiotoxicity [17,[26][27][28]. Although previous studies have shown an increase of approximately 33% in cTnI after the use of anticancer drugs in patients with aggressive malignant diseases, troponin did not present a signi cant difference between the analyzed times [17], possibly due to the small sample population.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, is usually increased after high doses of chemotherapy, being a recognized independent biomarker of cardiotoxicity [17,[26][27][28]. Although previous studies have shown an increase of approximately 33% in cTnI after the use of anticancer drugs in patients with aggressive malignant diseases, troponin did not present a signi cant difference between the analyzed times [17], possibly due to the small sample population. Such ndings remain in correlation with the RDW, without showing a signi cant difference.…”

Section: Discussionmentioning

confidence: 99%

“…an in ammation-associated marker [16] with the potential to aid prognosis and overall mortality in these diseases, including several types of cancers [15]. In 2016, a meta-analysis of 17 retrospective studies indicated that high RDW signi cantly predicted poor overall survival, poor cancer-speci c survival, poor disease-free survival, poor event-free survival, and poor cancer progression-free survival [15,17]. This result reinforces the relationship between RDW and cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation Of The RDW Index (Red Cell Distribution Width) In The Prognosis Of Patients With Breast Cancer

Ferreira

Silva

Sabino

et al. 2023

Preprint

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Background: Breast cancer is the most common cancer and the most frequent cause of death in women. The tumor inflammatory process is associated with the initiation, progression and maintenance of cancer and Red cell distribution width (RDW) index is one of the parameters that is altered in progressive inflammatory states. Objective: To correlate RDW and inflammatory markers in women with breast cancer as aid in monitoring adverse events associated with the use of doxorubicin. Methods: Database analysis of a prospective study of 80 women with breast malignancy undergoing doxorubicin-based chemotherapy, in a public hospital, from June 2015 to June 2018. To assess the significance of RDW in cancer and to correlate it with the variables: - plasma levels of C-reactive protein (CRP), galectin 3, myeloperoxidase, NT-terminal B-type natriuretic peptide and troponin I (cTnI). Results: Analysis by marginal logistic regression, significant differences were found over time for the variables - RDW (p<0.001), PCR (p=0.036). In the comparative analysis of correlation between the different variables, there was a significant, negative difference between RDW and CRP at time T1, with a decrease in CRP over time, while RDW showed an increase. Conclusion: The RDW is a simple test, easy to obtain and economical as part of the hemogram. The present study presented significant differences in providing additional information regarding the laboratory evolution of breast cancer and variations in its evolution regarding the therapeutic response.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation Of The RDW Index (Red Cell Distribution Width) In The Prognosis Of Patients With Breast Cancer

Ferreira

Silva

Sabino

et al. 2023

Preprint

Self Cite

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“…Many developments and milestones have been achieved in discovering compounds with effective anticancer therapeutic properties. Although a lot of such potent drugs such as doxorubicin and cisplatin were discovered several years ago and are still used clinically to treat different kinds of cancers; they are often limited by severe side effects on healthy cells [1,2]. Recently, the research focus has shifted to develop target specific treatments.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

et al. 2022

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Tumour cells maintain a local hypoxic and acidic microenvironment which plays a crucial role in cancer progression and drug resistance. Urease is a metallohydrolases that catalyses the hydrolysis of urea into ammonia and carbon dioxide, causing an abrupt increase of pH. This enzymatic activity can be employed to target the acidic tumour microenvironment. In this study, we present the anticancer activities of urease mimetic cobalt (III) complexes on A549 cells. The cells were treated with different doses of cobalt (III) complexes to observe the cytotoxicity. The change in cellular morphology was observed using an inverted microscope. The cell death induced by these complexes was analysed through ATP proliferation, LDH release and caspase 3/7 activity. The effect of extracellular alkalinization by the cobalt (III) complexes on the efficacy of the weakly basic drug, doxorubicin (dox) was also evaluated. This combination therapy of dox with cobalt (III) complexes resulted in enhanced apoptosis in A549 cells, as evidenced by elevated caspase 3/7 activity in treated groups. The study confirms the urease mimicking anticancer activity of cobalt (III) complexes by neutralizing the tumour microenvironment. This study will motivate the applications of transition metal-based enzyme mimics in targeting the tumour microenvironment for effective anticancer treatments.

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Hemostatic status in women with breast cancer and cardiotoxicity associated to doxorubicin-based chemotherapy – A one-year follow-up study

Pestana

Duarte

Alves

et al. 2022

Thrombosis Research

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Identification of Clinical and Laboratory Variables Associated with Cardiotoxicity Events Due to Doxorubicin in Breast Cancer Patients: A 1-Year Follow-Up Study

Cited by 8 publications

References 36 publications

Evaluation Of The RDW Index (Red Cell Distribution Width) In The Prognosis Of Patients With Breast Cancer

Evaluation Of The RDW Index (Red Cell Distribution Width) In The Prognosis Of Patients With Breast Cancer

Anticancer Activity of Urease Mimetic Cobalt (III) Complexes on A549-Lung Cancer Cells: Targeting the Acidic Microenvironment

Hemostatic status in women with breast cancer and cardiotoxicity associated to doxorubicin-based chemotherapy – A one-year follow-up study

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