2021
DOI: 10.1186/s12863-021-00986-z
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Identification of common microRNA between COPD and non-small cell lung cancer through pathway enrichment analysis

Abstract: Background Different factors have been introduced which influence the pathogenesis of chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). COPD as an independent factor is involved in the development of lung cancer. Moreover, there are certain resemblances between NSCLC and COPD, such as growth factors, activation of intracellular pathways, as well as epigenetic factors. One of the best approaches to understand the possible shared pathogenesis routes between COPD… Show more

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Cited by 15 publications
(13 citation statements)
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“…This overlap of miR-200c and miR-449c between COPD and asthma is probably due to their role in regulating key inflammatory responses in both diseases. In relation to other lung diseases, COPD is known to be a risk factor for developing lung cancer, especially for non-small cell lung cancer (NSCLC), and a common miRNA signature has been identified between both diseases by “miRNA set enrichment analysis” [ 35 ]. Of note, our three-miRNA signature (miR-200c-3p, miR-449c-5p, and miR-320c) is not present in that COPD-NSCLC panel, thus highlighting their potential use as biomarkers specifics of COPD only.…”
Section: Discussionmentioning
confidence: 99%
“…This overlap of miR-200c and miR-449c between COPD and asthma is probably due to their role in regulating key inflammatory responses in both diseases. In relation to other lung diseases, COPD is known to be a risk factor for developing lung cancer, especially for non-small cell lung cancer (NSCLC), and a common miRNA signature has been identified between both diseases by “miRNA set enrichment analysis” [ 35 ]. Of note, our three-miRNA signature (miR-200c-3p, miR-449c-5p, and miR-320c) is not present in that COPD-NSCLC panel, thus highlighting their potential use as biomarkers specifics of COPD only.…”
Section: Discussionmentioning
confidence: 99%
“…It is worth noting that changes in respiratory epigenetic profiles such as DNA methylation, histone modification and microRNAs (miRNA) are likely to contribute to the altered differentiation and pro-inflammatory response in severe COPD. Perturbations in histone acetylation (HAT)/histone deacetylase (HDAC), methyltransferase (HMT) and histone demethylase (HDM) activities have been demonstrated to regulate many chromatin-dependent processes, including transcription, recombination and DNA repair (48)(49)(50). In COPD, cigarette smoke, accelerated aging and other environmental factors such as diet-modulated oxidative stress play a role in the pathogenesis of severe COPD (48,49).…”
Section: Discussionmentioning
confidence: 99%
“…In COPD, cigarette smoke, accelerated aging and other environmental factors such as diet-modulated oxidative stress play a role in the pathogenesis of severe COPD (48,49). Consequently, oxidativeg genome-wide epigenetic profiles in severe COPD airway epithelium would provide a great platform for potential the stress can regulate the activity of HATs and HDACs and enhance NF-B-dependent pro-inflammatory gene transcription such as IL-8 and TNFα (48)(49)(50). MiRNA-125a and -b have been shown to inhibit A20 and MAVS.…”
Section: Discussionmentioning
confidence: 99%
“…The prevention and cure of CHD are facing severe problems and challenges. Therefore, there is an urgent need to With the innovation and development of DNA sequencing and chip technology, bioinformatics methods have been extensively employed for research related to the various chronic diseases, such as non-small-cell lung cancer [18], gastric cancer [19], sepsis [20], pressure hydrocephalus [21], amyotrophic lateral sclerosis [22], schizophrenia [23], hypertension [24], hypertrophic cardiomyopathy [25], and pulmonary artery high-pressure disease [26]. In the current study, we have used multiple bioinformatics methods to determine the potential biological mechanisms of CHD.…”
Section: Discussionmentioning
confidence: 99%