Introduction/Objective. To evaluate sonographic and laboratory findings as
predictors of complicated and uncomplicated appendicitis in order to decide
on further treatment options. Methods. This is a retrospective cohort study
of 174 pediatric patients who had laboratory tests and ultrasound done
before appendectomy in one year period. Results were compared with the
intraoperative and histopathological findings of complicated (gangrenous or
perforated) or uncomplicated (phlegmonous) appendicitis and assessed by
binary logistic regression with backward elimination. The initial model
included eight predictors. After backward elimination four remained:
periappendiceal fluid, hyperechoic periappendiceal fat, white blood cell
(WBC) count and C-reactive protein (CRP). The final model included the
interaction between periappendiceal fluid and hyperechoic periappendiceal
fat. Diagnostic performance of each parameter was presented with sensitivity
and specificity. Results. Out of all patients, 86 had uncomplicated and 88
had complicated appendicitis (37 gangrenous and 51 perforated). In the final
model three predictors were significantly associated with complicated
appendicitis: interaction between periappendiceal fluid and hyperechoic
periappendiceal fat, WBC count > 11 ? 109 / l, and CRP > 100 mg/l. Inclusion
of interaction between periappendiceal fluid and hyperechoic periappendiceal
fat excluded them as individual predictors. The maximum outside appendiceal
diameter of more than 6mm had the highest sensitivity (93.2%), while wall
thickness > 3 mm was the most specific (95.2%). Conclusion. Using
periapendiceal fluid and hyperechoic periappendiceal fat as sonographic
predictors and WBC and CRP as laboratory predictors can differentiate
uncomplicated from complicated appendicitis in children and help a physician
decide on antibiotic or surgical treatment.