Identification of Compounds in <i>Coleus forskohlii</i> Extract Involved in the Induction of Hepatic CYP and Fatty Liver in Mice

Abstract

Introduction There has been a recent increase in the use of herbal dietary supplements 1 , as consumers perceive the term natural to indicate safety and herbal ingredients are believed to be effective due to their long use in complementary and alternative medicines. However, herbal ingredients are not subjected to routine safety examination, and recent studies have revealed that herbal products, especially those used for weight loss, can cause adverse events such as serious hepatic failure 2. In fact, hepatic failure induced by herbal dietary supplements reportedly accounts for 20 of hepatotoxicity cases in the United States 3. With the increasing use of herbal dietary supplements, ensuring their safety is of topical importance. Herbs are composed of many unidentified compounds and the chemical composition of herbal ingredients varies depending on the production location, harvest time, and preparation by individual manufacturers 4, 5. Furthermore, herbal supplement products are generally produced as

Comparison of CYP Induction by <i>Coleus forskohlii</i> Extract and Recovery in the Small Intestine and Liver of Mice

“…CYP gene expression is transcriptionally regulated by the pregnane X receptor (PXR) and the constitutive androstane receptor. It has been reported that mouse Cyp3a11 is a PXR-regulated gene, 36) and CFE induction of CYP has been shown to involve PXR. 23) Differences in the CFE dose required for CYP induction between the intestine and liver may be due to differences in transcriptional regulation of the CYP gene.…”