Identification of contributing factors, microorganisms and antimicrobial resistance involved in the complication of diabetic foot ulcer treatment

Microencapsulated Bilberry and Chokeberry Leaf Extracts with Potential Health Benefits

“…The additional antimicrobial potential could be considered, according to the higher rate of microbial infections and the tendency to develop complications in diabetic patients compared with non-diabetic ones, especially skin changes and diabetic wounds [4]. The most common and complex skin condition associated with hyperglycemiarelated diseases is diabetic foot ulcer (DFU), which leads to limb amputation for about 50-70% of diabetic patients [5,6]. Infections, which occasionally have a polymicrobial foundation, are the leading cause of amputation in DFU [5,7].…”

“…The most common and complex skin condition associated with hyperglycemiarelated diseases is diabetic foot ulcer (DFU), which leads to limb amputation for about 50-70% of diabetic patients [5,6]. Infections, which occasionally have a polymicrobial foundation, are the leading cause of amputation in DFU [5,7]. Antimicrobial resistance and the synergistic effect of these microorganisms represent the core of treatment failure [5]; therefore, there is a growing interest in finding new therapeutic options.…”

“…Infections, which occasionally have a polymicrobial foundation, are the leading cause of amputation in DFU [5,7]. Antimicrobial resistance and the synergistic effect of these microorganisms represent the core of treatment failure [5]; therefore, there is a growing interest in finding new therapeutic options. Last but not least, elevated glucose levels and oxidative stress induce the excessive production of advanced glycosylation end products (AGEPs), which appear to be the main cause of skin aging during life [8].…”