Identification of core genes and pathways in vacuum sealing drainage for the treatment of diabetic ulcers via bioinformatics and histological

Abstract

Diabetic ulcers are one of the common complications of diabetes mellitus and the foot is the main site of diabetic ulcers, which involves small and medium-sized arteries, peripheral nerves, microcirculation, etc., with a high rate of disability and high treatment costs. Multidisciplinary treatments spanning medicine and material science have been applied for diabetic foot, but the molecular mechanisms are unclear. Bioinformatics was used to evaluate the differentially expressed genes when the vacuum sealing drainage (VSD) technique was used for the treatment of diabetic foot, and histological studies were performed on tissues from six clinical diabetic foot patients before and after treatment with VSD. Interleukin-6 (IL6) and prostaglandin endoperoxide synthase 2 (PTGS2) were decreased and Epidermal Growth Factor Receptor (EGFR) was increased in patients with diabetic ulcers after VSD treatment. Notably, PTGS2 likely facilitates the healing of diabetic foot ulcers by controlling ferroptosis and may be both a significant prognostic marker and a potential therapeutic target.