With the advent of Industry 4.0, Blockchain is attracting Supply Chain (SC) practitioners and researchers thanks to its decentralized and trustworthy data governance features. As Blockchain adoption in SC is nascent, this article provides a Systematic Literature Review of the critical success factors for this phenomenon to help organizations meet its challenges. 56 selected articles were first thematically analyzed with NVivo to identify and conceptually categorize the factors. Then, we performed a social network analysis under VOSviewer to understand the research trends in our topic and explain the implicit ties between the identified factors. Finally, we inferred further theoretical implications of the analyzed literature in light of the ‘Technology, Organization, Environment’ framework. Hence, this study contributes to academic and practical knowledge by explaining the natures of the interdependent factors for Blockchain adoption in SC and of their potential links. We also propose opportunities for future research to extend our findings.