Background: Compared with patients with diabetes alone, patients with depression and diabetes have been shown to have poorer self-management and poor adherence to antidiabetics, lipid-lowering and antihypertensive treatment. Objectives: To investigate the prevalence and determinants of depression in patients with T2DM attending general hospitals, Tabuk, Saudi Arabia. Subjects and Methods: A cross-sectional community based study was conducted in Tabuk city, Saudi Arabia. A representative random sample of diabetic type 2 Saudi patients aged 18 years or above who attended out patients clinics of the two main general hospitals, belonging to Ministry of health (King Khalid and King Fahd specialist hospitals) throughout the study period (20 July to 20 Aug, 2016) constituted the population for the study. Data collection questionnaire developed by the researchers composed of two parts; Personal characteristics and diabetes-related variables. The Arabic version of the Patient Health Questionnaire (PHQ-9) was utilized for diagnosis of depression. Results: The study included 221 patients with a response rate of 61%. Approaching one-third of them (34.8%) aged between 50 and 59 years and 4.1% aged over 70 years. Males represent 51.6% of them. Obesity and extreme obesity were reported among 35.7% and 5.5% of the patients, respectively. Family history of depression was reported among 37 patients representing 16.7% of the respondents. Depression was reported among almost most of type 2 diabetic patients