2012
DOI: 10.1016/j.exppara.2012.02.004
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Identification of differentially expressed genes in Oncomelania hupensis chronically infected with Schistosoma japonicum

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Cited by 7 publications
(5 citation statements)
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“…Glutathione s-tranferases (GST) are also less expressed in this situation, a result contrary to our expectations since due to their role in cell detoxification and oxidative stress response, necessary for protecting the clam from the oxidative burst, we expected these levels to be up-regulated. However, and in agreement with our findings, some authors already demonstrated that in other mollusks, GST is up-regulated during the initial steps of infection but decreases when infection is established [57,58]. Other genes related with oxidative stress, such glutaredoxin a, aldo-keto reductase, hmgb-like protein, hephaestin, glucose dehydrogenase, peptide o-xylosyltransferase-like or agglutination (hemagglutinin amebocyte aggregation [59]) and anti-apoptosis related genes (e.g.…”
Section: Resultssupporting
confidence: 93%
“…Glutathione s-tranferases (GST) are also less expressed in this situation, a result contrary to our expectations since due to their role in cell detoxification and oxidative stress response, necessary for protecting the clam from the oxidative burst, we expected these levels to be up-regulated. However, and in agreement with our findings, some authors already demonstrated that in other mollusks, GST is up-regulated during the initial steps of infection but decreases when infection is established [57,58]. Other genes related with oxidative stress, such glutaredoxin a, aldo-keto reductase, hmgb-like protein, hephaestin, glucose dehydrogenase, peptide o-xylosyltransferase-like or agglutination (hemagglutinin amebocyte aggregation [59]) and anti-apoptosis related genes (e.g.…”
Section: Resultssupporting
confidence: 93%
“…Previously available data included 1,432 EST sequences from an O . hupensis hepatopancreas cDNA library [ 34 ] and head-foot SSH-library [ 35 ], partial and complete mitochondrial sequences [ 36 ], several internal transcribed spacer sequences[ 37 ], ribosomal RNA genes and microsatellites [ 38 , 39 ]. Due to the small proportion of mollusk-specific sequences in current databases, only 18.84% (47,906 unigenes) of 254,286 unigenes were successfully matched to homologs in Nt, Nr or Swiss-Prot.…”
Section: Discussionmentioning
confidence: 99%
“…RNA-Seq has also been used to identify Bg genes associated with a state of heightened innate immunity ( 62 ) or FREP (fibrinogen-related protein)-encoding genes from snails differing in their susceptibility to Sm ( 68 ). RNA-Seq studies have also now been undertaken with field-derived specimens of the major African vector snail Biomphalaria pfeifferi ( 6 ) and with the intermediate hosts for Schistosoma japonicum , Oncomelania hupensis ( 69 , 70 ). Recently, RNA-Seq has been used to explore responses of lab-reared Biomphalaria to Sm or Schistosoma rodhaini from sympatric or allopatric sources ( 71 ), and was used in a study of early (0.5-16 hours) exposure to Sm in BS-90 Bg to explore the interactions of BgPiwi and the retrotransposon nimbus in influencing resistance ( 72 ).…”
Section: Introductionmentioning
confidence: 99%