Identification of disulfidptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in colorectal cancer

Li, Ying; Tang, Mengyao; Dang, Wei; Zhu, Shu; Wang, Yunpeng

doi:10.1007/s00432-023-05211-1

Cited by 8 publications

(3 citation statements)

References 64 publications

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“…2.CRC: MXRA8, IGFBP5, MRC2, HTRA1, TNFAIP6, SLC3A7, GRP, APOD [ 23 ]; TRIP6, OXSM, MYH3, MYH4 [ 24 ]…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

“…Li et al have identified eight characteristic genes associated with disulfidptosis, including MXRA8, IGFBP5, MRC2, HTRA1, TNFAIP6, SLC3A7, GRP, and APOD. These genes are proposed to hold potential as novel biomarkers for colorectal cancer (CRC) [ 23 ]. Hu and colleagues have identified four disulfidptosis-related genes, TRIP6, OXSM, MYH3, and MYH4, which are speculated to not only offer potential insights into the survival rates of colorectal adenocarcinoma but might also play a role in influencing the tumor microenvironment, drug sensitivity, and immune landscape [ 24 ].…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

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Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Chen,

Ma,

Yang

et al. 2024

Biomark Res

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Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute carrier family 7 member 11 (SLC7A11) during glucose starvation. This accumulation causes extensive disulfide linkages between F-actins, resulting in their contraction and subsequent detachment from the cellular membrane, triggering cellular death. The RAC1-WRC axis is involved in this phenomenon. Disulfidptosis sparked growing interest due to its potential applications in a variety of pathologies, particularly oncology, neurodegenerative disorders, and metabolic anomalies. Nonetheless, the complexities of its regulatory pathways remain elusive, and its precise molecular targets have yet to be definitively identified. This manuscript aims to meticulously dissect the historical evolution, molecular underpinnings, regulatory frameworks, and potential implications of disulfidptosis in various disease contexts, illuminating its promise as a groundbreaking therapeutic pathway and target.

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“…2.CRC: MXRA8, IGFBP5, MRC2, HTRA1, TNFAIP6, SLC3A7, GRP, APOD [ 23 ]; TRIP6, OXSM, MYH3, MYH4 [ 24 ]…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

Section: Disulfidptosis and Diseasementioning

confidence: 99%

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Chen,

Ma,

Yang

et al. 2024

Biomark Res

View full text Add to dashboard Cite

show abstract

“…Researchers have observed that during glucose starvation, an abnormal accumulation of intracellular disulfide bonds disturbs the normal disulfide bonds between cytoskeletal proteins, ultimately leading to cell death. [25][26][27] Although the modulation of the tumor microenvironment (TME) by disulfidptosis has been observed and its prognostic features have been established in some cancers, [28][29][30] its specific role in GC and its underlying mechanisms have not been reported and require further investigation.…”

Section: Introductionmentioning

confidence: 99%

A disulfidptosis-related classification and risk signature identifies immunotherapy biomarkers and predicts prognosis in gastric cancer: An observational study

Chen,

Jiang

2024

Medicine

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Gastric cancer (GC) is one of the most prevalent types of cancer globally, often detected at advanced stages. However, its prognosis remains poor, necessitating the exploration of new biomarkers. Disulfidptosis, a recently identified form of programmed cell death, has not yet been investigated in relation to GC and its associated mechanisms. We analyzed and identified potential associations between disulfidptosis genes and GC clinical risk using TCGA (The Cancer Genome Atlas)-STAD (stomach adenocarcinoma) as the training set and GSE84433 as the validation set. In addition, we explored the prognostic value and potential biological mechanisms of disulfide genes in GC by consensus clustering, enrichment analysis, mutation histology analysis and immune infiltration analysis. Finally, we constructed a disulfidptosis-related risk signature (DRRS) to assess the association between risk class, survival prognosis, and immune infiltration. By utilizing data from 19 disulfidptosis-related genes, we successfully identified subgroups of C1 and C2 patients through consensus clustering. Notably, the 2 groups exhibited significant variations in terms of survival rates, immune scores, and immune cell infiltration. Subsequently, we developed a DRRS via LASSO (least absolute shrinkage and selection operator) regression analysis, incorporating PRICKLE1, NRP1, APOD, MISP3, and SERPINE1. This scoring system effectively distinguished individuals with high and low risks, as verified with a validation set. These findings strongly indicate a close association between disulfidptosis and the immune microenvironment of GC tumors. Moreover, the DRRS demonstrated commendable predictive capabilities for the survival outcomes of GC patients. In this study, we have identified the association between different subtypes of disulfidptosis and alterations in the GC immunotumour microenvironment. Furthermore, we have developed and verified the accuracy of the DRRS, a valuable tool for predicting survival, biological function, and immune infiltration in patients with GC. These findings contribute to a better comprehension of disulfidptosis and offer potential opportunities for innovative approaches in GC treatment.

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Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis

Tian,

Song,

She

et al. 2024

Apoptosis

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Identification of disulfidptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in colorectal cancer

Cited by 8 publications

References 64 publications

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

A disulfidptosis-related classification and risk signature identifies immunotherapy biomarkers and predicts prognosis in gastric cancer: An observational study

Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis

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