Identification of drug-related problems by a clinical pharmacist in addition to computerized alerts

Zaal, Rianne J.; Jansen, Manon A. A.; Essenberg, Marjolijn Duisenberg-van; Tijssen, Cees; Roukema, Jan A.; Bemt, Patricia M. L. A. van den

doi:10.1007/s11096-013-9798-4

Cited by 43 publications

(50 citation statements)

References 42 publications

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“…Efforts to increase the specificity of DDI alerts by understanding DDI burden and adding information regarding their clinical relevance should be encouraged . Adherence to the guidelines could also be enhanced by increasing the role of the pharmacist in responding to DDI alerts . Because the co‐medication of metoprolol–paroxetine/fluoxetine is still observed, a decision should be made whether the interaction is deemed sufficiently clinically significant to keep it in both surveillance systems, G‐Standard and Pharmabase.…”

Section: Discussionmentioning

confidence: 99%

The burden and management of cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interaction (DDI): co‐medication of metoprolol and paroxetine or fluoxetine in the elderly

Bahar

Bos

Borgsteede³

et al. 2017

Pharmacoepidemiology and Drug

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Section: Discussionmentioning

confidence: 99%

The burden and management of cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interaction (DDI): co‐medication of metoprolol and paroxetine or fluoxetine in the elderly

Bahar

Bos

Borgsteede³

et al. 2017

Pharmacoepidemiology and Drug

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“…Historically, CPOE use has improved patient safety, prevented medical errors, and facilitated communication between physicians and pharmacists . The PRESCRIB Project established an innovative strategy that further develops the CPOE capabilities introduced some years ago by our hospital pharmacy.…”

Section: Discussionmentioning

confidence: 87%

Computerized physician order entry-based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project

et al. 2014

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Computerized physician order entry (CPOE) applications are widely used to prevent medical errors. In our center, a CPOE system has been in use since 2009 on both the inpatient and outpatient levels. A new and simple alert was introduced in the CPOE system to notify healthcare providers of the potential risk of viral reactivation when prescribing biological therapies, thereby facilitating the request for a serological profile (hepatitis B surface antigen [HBsAg], anti-HBc, and anti-HBs) in patients who have not had these tests. Between May 2012 and May 2013, a total of 1,076 patients undergoing biological treatment were included in the implementation of the CPOE in our hospital, resulting in the identification of 4 HBsAg-positive and 69 anti-HBc-positive/HBsAg-negative patients, two of them with positive viral loads. Since the implementation of this alert system, over 90% of patients who were prescribed a biological drug (BD) have undergone serological screening to detect hepatitis B virus (HBV) infection. The use of the alert system has increased the screening rate from less than 50% to 94% for HBsAg and from less than 30% to 85% for anti-HBc in patients for whom a BD is prescribed. Six patients received prophylactic antiviral therapy. No patient had HBV reactivation. Conclusion: This study demonstrates the feasibility of implementing a CPOE system that has allowed our hospital to increase the rate of HBV screening. Its use has facilitated the identification of patients at high risk for HBV reactivation and permitted physicians to prescribe prophylactic measures according to current guidelines. (HEPATOLOGY 2014;60:106-113)

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“…Hepler and strand defines DRPs as "A drug related problem is an event or circumstances involving drug treatment that actually or potentially in DRPs frequency have been reported. Rianne reported 442 DRPs in 228 patients in study, 25 this showed 736 DRPs in 196 patients. 26 The lack of standardized method for identifying DRP restricts the possibility in such area.…”

Section: Drug Related Problemsmentioning

confidence: 90%

Drug Related Problems in Radio and Nuclear Pharmacy

Patel¹,

Bhatt²,

Sinha³

2018

IJOPP

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Background: Radiopharmaceutical plays a critical role in modern medicine primarily for the diagnostic purpose, but also for monitoring disease progression and response to treatment. Identification, resolution and prevention of medication related problems is a vital role of healthcare professionals Drug related problems are an important challenge that may affect morbidity and mortality, as well as the patient's quality of life. The Drug Related Problems recorded by the pharmacists were found to be of clinical significance lends support to actively including clinical pharmacists in the therapeutic health care team. Method: Data was collected in data collection form using patient's medication file. Patients visiting department of nuclear medicine Gujarat Cancer and Research Institute, Ahmedabad were recruited in study. Data was collected in data collection form By reviewing patient's medication file. Result: Total 65 patient included in the study and 146 DRPs identified in 56 (15.47%) patients. The frequency of Drug Related Problem was 2.60 per patient. Most common problems came to know were logistic problem(35.38%), repetition of report (35.38%), Imagine problem (37.69%), patient identifying problem (27.69%), dose selection problem (24.62%), administration problem (87.69%) and vein identifying problem (12.31%). Conclusion: It is concluded that apart from general medicines, Drug Related Problems also presented in nuclear and Radio Pharmaceutical product. Moreover there is a need to develop specific classification system to identify the Drug Related Problems associated with radio and nuclear pharmacy.

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Identification of drug-related problems by a clinical pharmacist in addition to computerized alerts

Abstract: As most DRPs identified by a clinical pharmacist were not detected in daily clinical practice by CPOE/CDSS, a clinical pharmacist contributes to reducing DRPs. The sensitivity of CPOE/CDSS to detect certain classes of problems should be optimized.

Cited by 43 publications

References 42 publications

The burden and management of cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interaction (DDI): co‐medication of metoprolol and paroxetine or fluoxetine in the elderly

The burden and management of cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interaction (DDI): co‐medication of metoprolol and paroxetine or fluoxetine in the elderly

Computerized physician order entry-based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project

Drug Related Problems in Radio and Nuclear Pharmacy

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