Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
Sophie Klemm,
Katja Evert,
Kirsten Utpatel
et al.
Abstract:Background
Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered insufficient for hepatocarcinogenesis. We aimed to characterize the process of N-Ras-dependent carcinogenesis in the liver and to identify potential therapeutic vulnerabilities.
Methods
NRAS V12 plasmid was delive… Show more
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