2021
DOI: 10.1101/2021.12.29.474463
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Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells

Abstract: Aberrations to endoplasmic/sarcoplasmic reticulum (ER/SR) calcium concentration can result in the departure of endogenous proteins in a phenomenon termed exodosis. Redistribution of the ER/SR proteome can have deleterious effects to cell function and cell viability, often contributing to disease pathogenesis. Many proteins prone to exodosis reside in the ER/SR via an ER retention/retrieval sequence (ERS) and are involved in protein folding, protein modification, and protein trafficking. While the consequences … Show more

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