Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer

Xin, Ying; Wang, Xueqiang; Meng, Kexin; Lv, Zhenye; Guan, Dandan

doi:10.1042/bsr20190303

Cited by 29 publications

(18 citation statements)

References 44 publications

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“…For breast cancer, several miRNAs have been demonstrated to play roles in its progression. miR-455-5p and miR-1255a were upregulated with poor overall survival, while the overexpression of their target genes was related to a good overall survival, which indicated the potential roles of mir-455-5p and miR-1255a in the therapy of breast cancer [10]. miR-331 is upregulated in breast cancer, and it has been demonstrated to be dysregulated in many other cancers, such as lung cancer, gastric cancer, and prostate cancer [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 92%

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

et al. 2020

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Background: With the increasing number of cases of breast cancer every year, the exploration of novel biomarkers has drawn attention. miR-331 has been demonstrated to play a role in various cancers, but its role in breast cancer is still unknown. Methods: In this study, we included 121 patients with breast cancer treated at Affiliated Hospital of Weifang Medical University. Breast cancer tissues and adjacent normal tissues were collected during the surgery. The expression of miR-331 in breast cancer tissues and cell lines was detected by qRT-PCR assay. Then, with the help of Kaplan-Meier survival and Cox regression analyses, the role of miR-331 in the prognosis of breast cancer was analyzed. Finally, the effect of miR-331 on cell proliferation, migration, and invasion was investigated with CCK-8 assay and transwell assay. Results: miR-331 was significantly upregulated in breast cancer tissues compared with normal tissues. The overexpression of miR-331 was associated with lymph node metastasis, TNM stage, and poor prognosis. From the results of Cox regression analyses, it was found that miR-331 served as an independent indicator in the prognosis of breast cancer. In addition, miR-331 was also found to be upregulated in breast cancer cells, which promoted cell proliferation, migration, and invasion of breast cancer. Conclusion: As shown from our data, miR-331 may be a potential prognostic biomarker in breast cancer. Moreover, the development and progression of breast cancer may involve miR-331. These findings suggest a novel therapeutic target for the treatment of breast cancer.

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Section: Introductionmentioning

confidence: 92%

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

et al. 2020

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“…Exosomes are vesicle-shaped structures with a diameter of 50–150 nm that can transport miRNAs as cargo. Various exosomal miRNAs have been identified in breast cancer such as exosomal miRNA-455-5p, -1255a, and -148a that can be used as therapeutic and diagnostic factors [ 110 , 111 ]. Exosomal miRNAs are capable of regulating PTEN expression in ensuring breast cancer malignancy.…”

Section: Microrna and Pten Relationshipmentioning

confidence: 99%

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

et al. 2021

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MicroRNAs (miRNAs) are well-known regulators of biological mechanisms with a small size of 19–24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer progression. miRNAs can function as tumor-suppressing or tumor-promoting factors in cancer via regulating molecular pathways. Breast and lung cancers are two malignant thoracic tumors in which the abnormal expression of miRNAs plays a significant role in their development. Phosphatase and tensin homolog (PTEN) is a tumor-suppressor factor that is capable of suppressing the growth, viability, and metastasis of cancer cells via downregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling. PTEN downregulation occurs in lung and breast cancers to promote PI3K/Akt expression, leading to uncontrolled proliferation, metastasis, and their resistance to chemotherapy and radiotherapy. miRNAs as upstream mediators of PTEN can dually induce/inhibit PTEN signaling in affecting the malignant behavior of lung and breast cancer cells. Furthermore, long non-coding RNAs and circular RNAs can regulate the miRNA/PTEN axis in lung and breast cancer cells. It seems that anti-tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression. These topics are discussed in the current review with a focus on molecular pathways.

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“…Accumulating evidence demonstrated that miRNAs play an important role in tumor growth and metastasis by regulating protein expression at the post-transcriptional level 42 . For instance, miR-455-5p is an high conserved miRNA and play critical roles in multiple tumors development and progression 25 , 27 , 32 - 35 , 39 , 43 . Yet, the expression profile and role of miR-455-5p in CCA development and progression remains largely unknown.…”

Section: Disscusionmentioning

confidence: 99%

“…Moreover, we demonstrated that PPP1R12A, a subunit of myosin phosphatase that play an critical role in regulating cell cycle and migration 25 , 34 , 39 , was a new direct target of miR-455-5p and PPP1R12A expression was negatively correlated with miR-455-5p in CCA tissues. Indeed, previous studies found that PPP1R12A interacted with insulin receptor substrate 1-insulin-like growth factor 1 receptor (IRS1-IGF1R) complex and mediated the process of IRS1 dephosphorylation, promoting PI3K/AKT cascade activation and in turn led to tumor cell proliferation and tumor growth 43 , 48 . In gastric cancer (GC) cells, silencing PPP1R12A inhibited GC cells proliferation by promoting cyclin D1 and c-myc expression to block the cell cycle 49 .…”

Section: Disscusionmentioning

confidence: 99%

MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects

Deng¹,

Zuo²,

Pei³

et al. 2021

J. Cancer

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Fully understanding the mechanism of how Cholangiocarcinoma (CCA) development and discovering promising therapeutic drugs are important to improve patients' survival time. This study identifies that microRNA-455-5p (miR-455-5p) targets protein phosphatase 1 regulatory subunit 12A (PPP1R12A), an effect that represses mitogen-activated protein kinase (MAPK) and PI3K/AKT pathway activation, thereby controlling CCA cells survival and metastasis. Moreover, miR-455-5p expression is reduced in CCA tissues and negative correlation with PPP1R12A and PPP1R12A knockdown phenotypic mimics miR-455-5p' effects on CCA cells. Furthermore, we demonstrate that galangin inhibits CCA growth both in vitro and in vivo , which is associated with increased miR-455-5p and repressed PPP1R12A expression. In support, overexpression of miR-455-5p abrogates those galangin-mediated anti-CCA effects. These findings establish an essential role of miR-455-5p in CCA development and galangin may provide a potential therapeutic adjuvant agent for anti-CCA treatment.

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Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer

Cited by 29 publications

References 44 publications

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

Overexpression of miR-331 Indicates Poor Prognosis and Promotes Progression of Breast Cancer

Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers

MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects

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