Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction

Pinelli, A

doi:10.4172/2155-9880.1000202

Cited by 5 publications

(5 citation statements)

References 25 publications

(35 reference statements)

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“…Interestingly, LCN2 has been characterized as the most substantially elevated protein in the brain of mice after an LPS challenge and showed neuroprotective effects during systemic inflammation [ 10 ]. The model also demonstrated binding of LCN2 to MMP9 [ 11 ], a collagen-degrading enzyme known to disrupt the blood–brain barrier and a pharmacologic target of propofol. Propofol is known to decrease the expression of the MMP9 protein [ 12 , 13 ] and the model suggests protective effects regarding neuroinflammation and the development of septic encephalopathy in the ICU.…”

Section: Discussionmentioning

confidence: 99%

Molecular RNA Correlates of the SOFA Score in Patients with Sepsis

et al. 2021

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The most common scoring system for critically ill patients is the Sequential Organ Failure Assessment (SOFA) score. Little is known about specific molecular signaling networks underlying the SOFA criteria. We characterized these networks and identified specific key regulatory molecules. We prospectively studied seven patients with sepsis and six controls with high-throughput RNA sequencing (RNAseq). Quantitative reverse transcription PCR (RT-qPCR) confirmation was performed in a second independent cohort. Differentially and significantly expressed miRNAs and their target mRNA transcripts were filtered for admission SOFA criteria and marker RNAs for the respective criteria identified. We bioinformatically constructed molecular signaling networks specifically reflecting these criteria followed by RT-qPCR confirmation of RNAs with important regulatory functions in the networks in the second cohort. RNAseq identified 82 miRNAs (45% upregulated) and 3254 mRNAs (50% upregulated) differentially expressed between sepsis patients and controls. Bioinformatic analysis characterized 6 miRNAs and 76 mRNA target transcripts specific for the SOFA criteria. RT-qPCR validated miRNA and mRNAs included IGFBP2 (respiratory system); MMP9 and PDE4B (nervous system); PPARG (cardiovascular system); AKR1B1, ANXA1, and LNC2/NGAL (acute kidney injury); GFER/ALR (liver); and miR-30c-3p (coagulopathy). There are specific canonical networks underlying the SOFA score. Key regulatory miRNA and mRNA transcripts support its biologic validity.

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Section: Discussionmentioning

confidence: 99%

Molecular RNA Correlates of the SOFA Score in Patients with Sepsis

et al. 2021

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“…Atherosclerotic plaque instability plays a major role in the pathogenesis of cardiovascular diseases such as myocardial ischemia, acute myocardial infarction, heart failure, and cerebrovascular accidents . Inflammation is a critical part of plaque initiation and the transition of stable plaque to a vulnerable plaque .…”

Section: Clinical Applicationsmentioning

confidence: 99%

Emerging applications for ferumoxytol as a contrast agent in MRI

Bashir

Bhatti

Marin

et al. 2014

Magnetic Resonance Imaging

317

251

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Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent initially approved by the Food and Drug Administration (FDA) as an iron replacement therapy for patients with anemia due to chronic renal failure. Recently, ferumoxytol has been investigated extensively as an intravenous contrast agent in magnetic resonance imaging (MRI). Since it causes regional T1 and T2 * shortening in vivo, conventional pulse sequences can be used following ferumoxytol administration to demonstrate signal enhancement or loss. Ferumoxytol can be administered as a rapid bolus and has a long intravascular half-life on the order of 14-15 hours, making it a potentially useful agent for vascular and perfusion-weighted MRI. In comparison to other USPIOs, ferumoxytol is less limited by allergic and idiosyncratic reactions. Furthermore, since ferumoxytol is an iron-based agent with no potential for causing nephrogenic systemic fibrosis, it may be useful as an alternative to gadolinium-based contrast agents in patients with compromised renal function. Ferumoxytol is ultimately taken up by macrophages/the reticuloendothelial system in the liver, spleen, and lymph nodes, and this uptake mechanism is being explored as a novel imaging technique for vascular lesions, tumors, and lymph nodes. This article reviews the properties of ferumoxytol relevant to MRI as well as many of the uses for the agent currently under investigation.

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“…19 Therefore, local MMP-9 indirectly enhances tissue factor activity, resulting in the formation of thrombogenic features. 19,20 Abundant local MMP-9 could cause massive red thrombosis resulting in STEMI, whereas other plaques shedding small amounts of MMP-9 may cause less red thrombosis, resulting in NSTEMI.…”

Section: Local Mmp-9 and Stemimentioning

confidence: 99%

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment–Elevation Myocardial Infarction

Nishiguchi

Tanaka

Taruya

et al. 2016

ATVB

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Objective-Early clinical presentation of ST-segment-elevation myocardial infarction (STEMI) and non-ST-segmentelevation myocardial infarction affects patient management. Although local inflammatory activities are involved in the onset of MI, little is known about their impact on early clinical presentation. This study aimed to investigate whether local inflammatory activities affect early clinical presentation. Approach and Results-This study comprised 94 and 17 patients with MI (STEMI, 69; non-STEMI, 25) and stable angina pectoris, respectively. We simultaneously investigated the culprit lesion morphologies using optical coherence tomography and inflammatory activities assessed by shedding matrix metalloproteinase 9 (MMP-9) and myeloperoxidase into the coronary circulation before and after stenting. Prevalence of plaque rupture, thin-cap fibroatheroma, and lipid arc or macrophage count was higher in patients with STEMI and non-STEMI than in those with stable angina pectoris.Red thrombus was frequently observed in STEMI compared with others. Local MMP-9 levels were significantly higher than systemic levels (systemic, 42.

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Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction

Cited by 5 publications

References 25 publications

Molecular RNA Correlates of the SOFA Score in Patients with Sepsis

Molecular RNA Correlates of the SOFA Score in Patients with Sepsis

Emerging applications for ferumoxytol as a contrast agent in MRI

Local Matrix Metalloproteinase 9 Level Determines Early Clinical Presentation of ST-Segment–Elevation Myocardial Infarction

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