Human perception in high‐rise buildings during far‐field long‐period earthquake ground motions often induces psychological discomfort, including fear and anxiety. A comprehensive understanding on human perception of seismic events is vital for city planning and emergency management, facilitating effective evacuation plans and minimizing stampede risks. This study addresses a gap by employing the seismic fragility analysis method to delineate how human perception in high‐rise buildings is affected during far‐field long‐period ground motions. The methodology involves several key steps. First, the far‐field long‐period earthquake ground motion was identified by detecting the later‐arriving surface waves, and a series of records were selected from the next generation attenuation (NGA) West‐2 ground motion database of the Pacific Earthquake Engineering Research center. Then, a high‐rise building in Shanghai, China was modeled using ETABS 20. Through the linear‐elastic time history analysis, the structural seismic response at each floor was computed. Furthermore, human perception thresholds to vibration were introduced to assess the degree of human perception at each floor, illustrating the difference of human perception to seismic tremor at different floors. Finally, a novel earthquake intensity measure (IM), namely average response spectrum intensity (ARSI) within the vibration period ranging from 0.1 s to 10 s was introduced to generate seismic fragility curves for human perception. According to the investigation, it was found that the corner frequency and the associated energy ratio are useful indicators to identify the far‐field long‐period earthquake ground motions. The ARSI is an effective parameter to assess human perception to seismic tremor compared to the spectral acceleration at a given fundamental period. The generated seismic fragility analysis can provide a complete and thorough understanding on the probability of people that should be evacuated under different earthquake intensity levels. The probability of human perception at different floors varies along the building height, demonstrating the difficulty to make crowd evacuation plan in practice. This insight is vital for understanding and mitigating seismic concerns in high‐rise buildings, particularly in low‐to‐moderate seismicity regions.