2021
DOI: 10.1186/s12935-021-01863-6
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Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma

Abstract: Background Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide with poor prognosis. The pathogenesis of human papillomavirus (HPV)-positive and HPV-negative HNSCCs differs. However, few studies have considered the HPV status when identifying biomarkers for HNSCC. Thus, the identification of biomarkers for HPV-positive and HPV-negative HNSCCs is urgently needed. Methods Three microarray datasets from Gene Expression Omnibus (GE… Show more

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Cited by 9 publications
(9 citation statements)
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References 40 publications
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“…However, STAG3 overexpression is also a common event in various cancers [186]. In HNSCCs not stratified by HPV status, STAG3 expression is associated with improved overall survival and progression-free interval [143]. Conversely, high STAG3 expression is associated with poor prognosis, metastasis, and disease recurrence in colorectal cancer patients [187].…”
Section: Stag3mentioning
confidence: 99%
“…However, STAG3 overexpression is also a common event in various cancers [186]. In HNSCCs not stratified by HPV status, STAG3 expression is associated with improved overall survival and progression-free interval [143]. Conversely, high STAG3 expression is associated with poor prognosis, metastasis, and disease recurrence in colorectal cancer patients [187].…”
Section: Stag3mentioning
confidence: 99%
“…In another recent study, fostamatinib (which inhibits PLK1 as well as other serine-threonine kinases) was shown to be effective against the prostate cancer cell line (PC3) [102]. The anti-cancer activity of fostamatinib was also evident against head and neck squamous cell carcinoma [103], hepatocellular carcinoma [104], breast cancer [105], and diffuse large B cell lymphoma [106] cell lines. Moreover, a fostamatinib derivative, NSC765691, also exhibited antiproliferative activity against the panel of NCI-60 cell lines [107].…”
Section: Discussionmentioning
confidence: 98%
“…A gradual decrease in expression of TGF- β , TGF β R-I, and TGF β R-II was observed in the different stages of carcinogenesis. In cancer cells, there is a reduction in TGF β R-II levels, and this can promote the development and growth of oral cancer, acting as an indicator of differentiation and therefore of aggressive behavior [ 110 ]. Activation of the Wnt/ β -catenin pathway induces β -catenin release and subsequently cytoplasmic aggregation and its transport to the nucleus, through the interaction with certain genes (with inhibition of apoptosis and increase of cell proliferation) such as COX-2, cyclin D1, and cMyc [ 105 , 111 ].…”
Section: Risk Factors For Oral Cancer In Pediatric Dentistrymentioning
confidence: 99%