Identification of Furanoylfentanil and its Metabolites in Human Urine

Av, Labutin; Az, Temerdashev; Oa, Dukova; Ev, Suvorova; Vv, Nemihin

doi:10.4172/2161-0525.1000456

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…In this study, HepaRG cells produced more metabolites than HLMs (9 out of 17), as could have been expected. Nevertheless, all these additional HepaRG-derived Fu-F metabolites appear to be minor in vivo metabolites [18][19][20]. Similar observation concerning the limited contribution of HepaRG toward HLMs into NPS metabolism study has already been reported [39].…”

Section: Resultssupporting

confidence: 77%

“…carboxamide cleavage; b, piperidine ring cleavage; c, cleavage between the piperidine ring and the phenethyl rest; d, e, i, degradation of the piperidine ring; f, g, cleavage between the piperidine ring and the N-phenylfuran-2-carboxamide; j, elimination of H 2 O. The 3 last columns indicate previously reported Fu-F metabolites in literature [18][19][20] ( 1 fragmentation patterns not available owing to a too low in vitro production; 2 at least one of these isomers). View publication stats View publication stats…”

Section: Disclosure Of Interestmentioning

confidence: 98%

“…Indeed, the identification of Fu-F metabolites, which improves the efficiency of toxicological screening libraries, will enlarge the detection window of Fu-F in biological matrices after Fu-F intake. Data about Fu-F metabolism were recently reported [18][19][20]. The aim of this work is to investigate and compare possible CYP-and UGT-dependent metabolites of Fu-F by means of (i) analyses of both human liver microsomes (HLMs) and hepatic (HepaRG) cell line incubates using liquid chromatography with high-resolution mass detection (LC-HRMS) and (ii) confrontation to these recently reported data.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

Richeval

Gicquel

Hugbart

et al. 2018

CPB

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Section: Resultssupporting

confidence: 77%

Section: Disclosure Of Interestmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

Richeval

Gicquel

Hugbart

et al. 2018

CPB

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show abstract

“…This procedure is mostly performed in urine [103,107,128,138,145], but is also described for serum [103,107]. The solutions used are acetate buffer [145] and water [128], agitation or centrifugation being also performed. It should be noted the work of Fleming et al [128], with only 0.05 mL of urine, were able to quantify U-47700 with limits of detection and quantification of 1 ng/mL.…”

Section: Classic Sample Pre-treatment Techniques Applied To Determine Nso In Biological Specimensmentioning

confidence: 99%

Novel synthetic opioids – toxicological aspects and analysis

Tabarra

Soares

Rosado

et al. 2019

Forensic Sciences Research

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Over the past few years, there has been an emerging number of new psychoactive drugs. These drugs are frequently mentioned as “legal highs”, “herbal highs”, “bath salts” and “research chemicals”. They are mostly sold and advertised on online forums and on the dark web. The emerging new psychoactive substances are designed to mimic the effects of psychoactive groups, which are often abused drugs. Novel synthetic opioids are a new trend in this context and represent an alarming threat to public health. Given the wide number of fatalities related to these compounds reported within the last few years, it is an important task to accurately identify these compounds in biologic matrices in order to administer an effective treatment and reverse the respiratory depression caused by opioid related substances. Clinicians dealing with fentanyl intoxication cases should consider that it could, in fact, be a fentanyl analogue. For this reason, it is a helpful recommendation to include synthetic opioids in the routine toxicological screening procedures, including analysis in alternative matrices, if available, to investigate poly-drug use and possible tolerance to opioids. To address this public health problem, better international collaboration, effective legislation, effective investigation, control of suspicious “research chemicals” online forums and continuous community alertness are required. This article aims to review diverse reported fatalities associated with new synthetic opioids describing them in terms of pharmacology, metabolism, posology, available forms, as well as their toxic effects, highlighting the sample procedures and analytical techniques available for their detection and quantification in biological matrices.

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Furanylfentanyl in whole blood measured by GC–MS/MS after QuEChERS extraction in a fatal case

Dybowski

Dawidowicz

2020

Forensic Toxicol

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Identification of Furanoylfentanil and its Metabolites in Human Urine

Cited by 3 publications

References 8 publications

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

Novel synthetic opioids – toxicological aspects and analysis

Furanylfentanyl in whole blood measured by GC–MS/MS after QuEChERS extraction in a fatal case

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