Identification of GBV‐C hepatitis G RNA in chronic hepatitis C patients

Schleicher, Sabine; Chaves, Ricardo L.; Dehmer, Thomas; Gregor, Michael; Hess, Georg; Flehmig, Bertram

doi:10.1002/(sici)1096-9071(199609)50:1<71::aid-jmv12>3.3.co;2-j

Cited by 9 publications

(6 citation statements)

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“…HCV‐positive individuals are often coinfected with another flavivirus, GBV‐C, likely reflecting similarities in their mode of transmission 50,86‐95 . The detection of GBV‐C RNA in 25% of the HCV‐seropositive donors was therefore anticipated.…”

Section: Discussionmentioning

confidence: 99%

“…The infection appeared transient as the virus was not detected 1 week later. A high frequency (one in three cases) of GBV‐C transmission through blood transfusion was reminiscent of the more frequent detection of GBV‐C in groups at high risk for infection via the parenteral route, that is, IVDU, persons with hemophilia, and transfused patients 53‐55,58,86,97 . A limiting factor for the transmission of GBV‐C via blood transfusion may also be the presence of anti‐GBV‐C in the donors or recipients.…”

Section: Discussionmentioning

confidence: 99%

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Transfusion transmission of highly prevalent commensal human viruses

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Transfusion transmission of highly prevalent commensal human viruses

et al. 2010

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“…If HBV/HG V co-infection is generally rare (Karayiannis and Thomas, 1996;Schleicher et al, 1996), the low prevalence of HGV infection in the hepatic carcinoma patients and other HBV carriers (similar to that in the blood donors and pregnant women) might have been predicted, hepatic carcinoma frequently being associated with HBV infection. It would also seem unlikely that HGV infection is a direct precursor of malignancy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of infection with among various groups in hepatitis G virus Thailand

Poovorawan¹

1998

Annals of Tropical Medicine And Parasitology

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Two research groups recently and independently, isolated a hepatotropic flavivirus from human sera. The two viruses, named GB virus C and hepatitis G virus (HGV), were subsequently discovered to represent the same virus, which was associated with acute and chronic hepatitis of the non-A-E type. The prevalences of infection with HGV have now been investigated in various groups of the Thai population, some of which [e.g. thalassaemic children, patients with chronic liver disease, carriers of antibodies to hepatitis B virus and/or hepatitis C virus (HCV), prostitutes and intravenous-drug users (IVDU)] were assumed to be at high risk. Samples of sera were investigated by reverse-transcriptase PCR, using four primers created from the 5' untranslated region of HGV. The prevalence of HGV infection among the healthy controls (1%-5%) was found to be much less than that among thalassaemic children (32.6%), asymptomatic carriers of anti-HCV (20.4%), IVDU (18.2%), aplastic anaemia patients (14.3%) and prostitutes (10%), although similar to that in patients with chronic liver disorders. These results confirm a parenteral route of transmission for HGV and emphasise the need for further research to determine the clinical significance of this virus.

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“…Parenteral transmission appears to be the most important mode3 9 and has been confirmed by sequence analysis 10. Thus, intravenous drug users are at particular risk2 11 12; in one series 16% of intravenous drug users were HGV RNA positive, increasing to 75% if they were anti-HBc positive and 99% where HCV antibody was also detected.…”

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confidence: 86%

Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus

Petrík

Guella

Wight

et al. 1998

Gut

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Background-A novel flavivirus has been described recently and designated hepatitis G virus (HGV). The virus is transmitted by the parenteral route but it is uncertain whether it is associated with chronic liver disease because liver biopsy is diYcult to justify in this group. Aims-To examine histological features of liver biopsy in patients infected with hepatitis C virus (HCV) according to the presence or absence of HCV and HGV RNA. Methods-One hundred and thirty one consecutive HCV carriers undergoing staging liver biopsy were studied retrospectively. In each, HCV RNA and HGV RNA were detected by reverse transcription polymerase chain reaction on serum samples collected at the time of biopsy. The presence of each RNA was correlated with histological features blind to the RNA results; individual histological features of inflammation or fibrosis were scored separately. Results-Nineteen patients were positive for both HGV and HCV RNA in serum, 91 were positive for HCV RNA alone, two were positive for HGV RNA alone, and 19 were negative for both RNA species. Neither age nor sex diVered between the groups; a greater proportion of intravenous drug users were HGV RNA positive, but this was not statistically significant. There was no eVect of HGV coinfection on the stage of fibrosis or any other histological parameter except steatosis; patients with HCV and HGV RNA had a higher mean score for fat than those patients with HCV RNA alone (p<0.05). Conclusions-HGV coinfection has no important eVects on histological features in chronic HCV carriers. It is unlikely that HGV infection causes chronic liver disease. (Gut 1998;42:103-106)

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Identification of GBV‐C hepatitis G RNA in chronic hepatitis C patients

Cited by 9 publications

References 0 publications

Transfusion transmission of highly prevalent commensal human viruses

Transfusion transmission of highly prevalent commensal human viruses

Prevalence of infection with among various groups in hepatitis G virus Thailand

Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus

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