2008
DOI: 10.1002/dvdy.21531
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Identification of genes involved in the ciliary trafficking of C. elegans PKD‐2

Abstract: Ciliary membrane proteins are important extracellular sensors, and defects in their localization may have profound developmental and physiological consequences. To determine how sensory receptors localize to cilia, we performed a forward genetic screen and identified eleven mutants with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel. Class A cil mutants exhibit defects in PKD-2::GFP somatodendritic localization while Class B cil mutants a… Show more

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Cited by 30 publications
(32 citation statements)
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“…Similarly, the transition zone composition and structures might be partly distinct in the two neuron types. Diversity in trafficking and localization mechanisms has also been suggested to play a role in targeting polycystin channels to the sensory cilia of C. elegans males (Bae et al, 2008;Bae et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, the transition zone composition and structures might be partly distinct in the two neuron types. Diversity in trafficking and localization mechanisms has also been suggested to play a role in targeting polycystin channels to the sensory cilia of C. elegans males (Bae et al, 2008;Bae et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Localization of nphp-1 and nphp-4 to some of these ciliated neurons also overlaps with localization of the cystoprotein orthologs polycystin-1 (lov-1) and polycystin-2 (pkd-2) and with many orthologs of Bardet-Biedl syndrome (BBS) proteins [91,93] similar to what has been described for lov-1 and pkd-2 mutants [92]. These data have been recently refined for specific neuronal cell type [91,93], and the necessity of nphp-1 and nphp-4 for morphologic integrity of ciliated neurons in C. elegans was demonstrated [94,95]. In addition, a role for nphp-4 in life span of the worm has been demonstrated [96].…”
Section: Animal Modelsmentioning
confidence: 77%
“…In these mutant backgrounds, the quantity of environmentally released EVs is significantly reduced (Wang et al, 2014) and PKD-2∷GFP accumulates in the ciliary base region, resulting in a similar ci liary l ocalization defective or Cil phenotype (Bae et al, 2008; Bae et al, 2006; Peden and Barr, 2005; Qin et al, 2005). Whether PKD-2∷GFP accumulates in the distal dendrite or cephalic lumen cannot be resolved by light microscopy.…”
Section: Regulation Of Ev Biogenesis Shedding and Releasementioning
confidence: 99%