2020
DOI: 10.1200/jco.2020.38.15_suppl.e14547
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Identification of genetic alterations in childhood and adolescence glioblastoma (GBM) using next generation sequencing strategy.

Abstract: e14547 Background: Glioblastoma (GBM) is the most aggressive brain malignancy with a heterogeneity molecular profile and accounts for no more than 3-5% of Central Nervous System tumors in children. Despite its rarity, pediatric GBM pertain different molecular genetics, outcome and effectiveness to therapies and remains an equally lethal tumor in children. Identification of genetic alterations in GBM of childhood and adolescence is important to refine molecular classification, define prognosis and therapeutic … Show more

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