Identification of genomic regions associated with feed efficiency in Nelore cattle

Oliveira, P. S. N.; Cesar, Aline Silva Mello; Nascimento, Michele Lopes do; Chaves, Amália Saturnino; Tizioto, P. C.; Túllio, R. R.; Lanna, Dante Pazzanese Duarte; Rosa, A. P. S. A. da; Sonstegard, Tad S.; Mourão, Gérson Barreto; Reecy, James M.; Garrick, Dorian J.; Mudadu, Maurício A.; Regitano, Luciana Correia de Almeida

doi:10.1186/s12863-014-0100-0

Cited by 76 publications

(75 citation statements)

References 76 publications

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“…Different measures of feed efficiency have been proposed1 and most of these traits have been reported to have at least moderate heritability in beef and dairy cattle23456, including estimates in our population from the Nelore breed7.…”

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confidence: 95%

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Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Tizioto

Coutinho

Oliveira

et al. 2016

Sci Rep

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Residual feed intake (RFI), a measure of feed efficiency (FE), is defined as the difference between the observed and the predictable feed intake considering size and growth of the animal. It is extremely important to beef production systems due to its impact on the allocation of land areas to alternative agricultural production, animal methane emissions, food demand and cost of production. Global differential gene expression analysis between high and low RFI groups (HRFI and LRFI: less and more efficient, respectively) revealed 73 differentially expressed (DE) annotated genes in Longissimus thoracis (LT) muscle of Nelore steers. These genes are involved in the overrepresented pathways Metabolism of Xenobiotics by Cytochrome P450 and Butanoate and Tryptophan Metabolism. Among the DE transcripts were several proteins related to mitochondrial function and the metabolism of lipids. Our findings indicate that observed gene expression differences are primarily related to metabolic processes underlying oxidative stress. Genes involved in the metabolism of xenobiotics and antioxidant mechanisms were primarily down-regulated, while genes responsible for lipid oxidation and ketogenesis were up-regulated in HRFI group. By using LT muscle, this study reinforces our previous findings using liver tissue and reveals new genes and likely tissue-specific regulators playing key-roles in these processes.

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confidence: 95%

“…Several candidate loci and genes associated with feed efficiency traits in Nelore cattle have been identified by these GWAS711. Most of the loci identified in these studies appear to be located in regulatory elements and may affect phenotype by contributing to variation in the expression levels of nearby key-genes.…”

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confidence: 99%

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Tizioto

Coutinho

Oliveira

et al. 2016

Sci Rep

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“…A complete description of the genetic and experimental design is given in De Oliveira et al (2014). In brief, 585 Nelore steers weighing 382.5 kg on average, the offspring of 34 sires, were used.…”

Section: Animals and Phenotypic Datamentioning

confidence: 99%

A single nucleotide polymorphism in NEUROD1 is associated with production traits in Nelore beef cattle

Junior

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Feed efficiency and carcass characteristics are latemeasured traits. The detection of molecular markers associated with them can help breeding programs to select animals early in life, and to predict breeding values with high accuracy. The objective of this study was to identify polymorphisms in the functional and positional candidate gene NEUROD1 (neurogenic differentiation 1), and investigate their associations with production traits in reference families of Nelore cattle. A total of 585 steers were used, from 34 sires chosen to represent the variability of this breed. By sequencing 14 animals with extreme residual feed intake (RFI) values, seven single nucleotide polymorphisms (SNPs) in NEUROD1 were identified. The investigation of marker effects on the target traits RFI, backfat thickness (BFT), ribeye area (REA), average body weight (ABW), and metabolic body weight (MBW) was performed with a mixed model using the restricted maximum likelihood method. SNP1062, which changes cytosine for guanine, had no significant association with RFI or REA. However, we found an additive effect on ABW (P ≤ 0.05) and MBW (P ≤ 0.05), with an estimated allele substitution effect of -1.59 and -0.93 kg 0.75 , respectively. A dominant effect of this SNP for BFT was also found (P ≤ 0.010). Our results are the first that identify NEUROD1 as a candidate that affects BFT, ABW, and MBW. Once confirmed, the inclusion of this SNP in dense panels may improve the accuracy of genomic selection for these traits in Nelore beef cattle as this SNP is not currently represented on SNP chips.

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“…We also found enriched processes involving GTP ( HAWKE et al, 2006;ROMBERG et al, 2014;SUZUKI;KAZIRO;KOIDE, 2000). The impact on calcium content is especially notable as it affects MT through postmortem protein degradation in skeletal muscle TIZIOTO et al, 2014). A representative example is the proteolysis-associated ATP/GTP binding protein-like 3 gene (AGBL3), present in less copies in Korean beef cattle (Hanwoo) when compared to Holstein dairy breed (CHOI et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The remarkable influence in postmortem protein degradation, from CAPN1 and CAST, can partially explain the association with meat tenderness (TIZIOTO et al, 2014 …”

Section: Discussionmentioning

confidence: 99%

Identification of CNVs in the Nelore genome and its association with meat tenderness

Silva¹

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Identification of genomic regions associated with feed efficiency in Nelore cattle

Cited by 76 publications

References 76 publications

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake

A single nucleotide polymorphism in NEUROD1 is associated with production traits in Nelore beef cattle

Identification of CNVs in the Nelore genome and its association with meat tenderness

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