Identification of Gingerols in Ginger (Zingiber officinale Roscoe) by High Performance Liquid Chromatography-Tandem Mass Spectrometry and Pharmacologic Studies of its Aqueous Extract on the Rabbit Isolated Duodenum Contractility

Ahui, B; Konan, Brou André; ZannouTchoko, J; Amonkan, Kouao Augustin; KatiCoulibaly, A

doi:10.5455/jppa.20130228065221

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Jiang et al 2005 [25]516.09Methyl-6-gingerol308307 [M-H]-L. B., Ahui M. et al 2013 [27]619.247- Paradol292291 [M-H]-Tanaka et al 2015 [28]719.86Curcumin368367 [M-H]-Herebian et al 2009 [29]822.17Methyl diacetoxy-6-gingerdiol394393 [M-H]-Tanaka et al 2015 [28]922.8810-gingerol350349 [M-H]-H. Jiang et al 2005 [25]TAO et al 2009 [26]L.…”

Section: Resultsmentioning

confidence: 99%

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A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

Aborehab

Bishbishy

Refaiy

et al. 2017

BMC Complement Altern Med

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BackgroundHerbal treatment may have a chondroprotective and therapeutic effect on Osteoarthritis (OA). We investigated the mechanism of action of ginger and curcumin rhizomes cultivated in Egypt in treatment of OA in rat model.MethodsThirty-five albino rats were intra-articularly injected with Monosodium Iodoacetate in the knee joint. Ginger and curcumin was orally administered at doses of 200 and 400 mg/kg (F200 and F400). Serum levels of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1β) and superoxide dismutase activity (SOD) were measured using ELISA. The composition of the herbal formula hydro-ethanolic extract was characterized using UPLC-ESI-MS. Histopathological changes in injected joints was examined using routine histopathology. Statistical analysis was performed using one-way ANOVA.ResultsSerum levels of COMP, HA, MPO, MDA, and IL-1β were significantly decreased in F 200, F 400 and V groups when compared to OA group (P value <0.0001). On the other hand SOD levels were significantly elevated in treated groups compared to OA groups (P value <0.0001).ConclusionsThe ginger/curcumin at 1:1 had chondroprotective effect via anti-inflammatory and antioxidant effect in rat OA model. Further pharmacological and clinical studies are needed to evaluate this effect.

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Section: Resultsmentioning

confidence: 99%

“…Jiang et al 2005 [25]TAO et al 2009 [26]L. B., Ahui M. et al 2013 [27]1023.66-Paradol278277 [M-H]-TAO et al 2009 [26]Tanaka et al 2015 [25]1126.29Dihydrocurumin370369 [M-H]-Herebian et al 2009 [29] …”

Section: Resultsmentioning

confidence: 99%

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

Aborehab

Bishbishy

Refaiy

et al. 2017

BMC Complement Altern Med

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Zingiber officinale

Lim¹

2016

Edible Medicinal and Non-Medicinal Plants

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Characterization of phenolic compounds from normal ginger (Zingiber officinale Rosc.) and black ginger (Kaempferia parviflora Wall.) using UPLC–DAD–QToF–MS

Asamenew

Kim

Lee

et al. 2018

Eur Food Res Technol

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Zingiberaceae is the large diverse family comprised of rhizomatous plants with a higher concentration of phenolic compounds. The normal ginger (Zingiber officinale Rosc.) and black ginger (Kaempferia parviflora Wall.) belongs to this family and have similar morphological characteristics of rhizome, but their phenolic composition revealed differently. On this study, the phenolic composition of normal ginger (from Ethiopia and Korea) and black gingers (from Korea and Thailand) were profiled using ultra performance liquid chromatography coupled with diode array detector, quadrupole time-of-flight mass spectrometry (UPLC-DAD-QToF-MS). The result revealed that gingerol-related phenolic acid was detected only in normal gingers while, the methoxyflavones were identified exclusively in black gingers. 6-gingerol, 8-gingerol, 10-gingerol, 1-dehydro-6-gingerdione, and diacetoxy-8-gingerdiol were the major constituents among 18 phenolic acids detected from normal gingers, and 3,5,7,3′,4′-pentamethoxyflavone and 5,7,4′-trimethoxyflavone were confirmed as predominant constituents among 13 methoxyflavones from black gingers. The total phenolic content was 434.7 and 698.1 mg/100 g dry weight (DW) in Korean and Ethiopian sample, respectively. The total methoxyflavone concentration was 4388.0 mg/100 g DW and 3940.2 mg/100 g DW in Korean and Thai black ginger sample, respectively. The higher concentration of methoxyflavones is from advanced biosynthetic pathway related to accumulated color of black ginger. In addition, new possible structural fragmentation was proposed for gingerol homologous series as additional pathway under the positive ionization mode, and further rationalized that ferulic acid moiety is the biosynthetic precursor. The result suggested that despite the morphological similarity, normal and black ginger showed distinct biosynthetic difference to synthesis their major secondary metabolites.Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s0021 7-018-3188-z) contains supplementary material, which is available to authorized users. Graphical AbstractKeywords Kaempferia parviflora Wall. · Phenolic compounds · UPLC-DAD-QToF-MS · Zingiberaceae · Zingiber officinale Rosc.

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Identification of Gingerols in Ginger (Zingiber officinale Roscoe) by High Performance Liquid Chromatography-Tandem Mass Spectrometry and Pharmacologic Studies of its Aqueous Extract on the Rabbit Isolated Duodenum Contractility

Cited by 6 publications

References 30 publications

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

Zingiber officinale

Characterization of phenolic compounds from normal ginger (Zingiber officinale Rosc.) and black ginger (Kaempferia parviflora Wall.) using UPLC–DAD–QToF–MS

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