Abstract:The seven trans-membrane spanning G protein couple receptors(GPCRs)
constitute the largest family of FDA approved drug targets to treat
numerous human diseases, including metabolic associated disorders. The
Melanocortin Receptor Accessory Protein 2 (MRAP2), a small single
transmembrane protein broadly expressed in multiple tissues has been
defined as a vital endocrine pivot of five melanocortin
receptors(MC1R-MC5R) and several other GPCRs in the regulation of
central neuronal appetite and peripheral energy hom… Show more
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