Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development

Fu, Yao; Miyazaki, Kouji; Chiba, Yuta; Funada, Keita; Yuta, Tomomi; Tian, Tian; Mizuta, Kanji; Kawahara, Jumpei; Zhang, Ling; Martin, Daniel; Iwamoto, Tsutomu; Takahashi, Ichiro; Fukumoto, Satoshi; Yoshizaki, Keigo

doi:10.1016/j.jbc.2023.104638

Cited by 4 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LYPD1 is a secreted protein, which was first reported to be expressed in the neurons of the central and peripheral nervous system 11 . It has also been reported to be highly expressed in the fallopian tube and preodontoblasts 12 , 13 . Although the precise roles of LYPD1 are not fully understood, it has been reported that LYPD1 is an important component of the molecular mechanisms that modulate anxiety, and that LYPD1 mutant mice show increased anxiety-related behavior 14 .…”

Section: Introductionmentioning

confidence: 98%

Association of serum Ly6/PLAUR domain-containing protein 1 levels with skin sclerosis in systemic sclerosis

Sugimori,

Omori,

Iwasawa

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Systemic sclerosis (SSc) is a connective tissue disease characterized by aberrant immune activation, vascular injury, and fibrosis of the skin and internal organs. Ly6/PLAUR domain-containing protein 1 (LYPD1) was reported to be secreted and to have various physiological functions such as anti-angiogenic effects. Here we investigated serum LYPD1 levels in SSc patients and the association of serum LYPD1 levels with clinical features of SSc. Serum samples were obtained from 75 SSc patients and 22 healthy individuals as controls. We measured serum LYPD1 levels using enzyme-linked immunosorbent assay kits. Then, the relationship between serum LYPD1 levels and clinical features of SSc was analyzed. Serum LYPD1 levels in diffuse cutaneous SSc (dcSSc) patients were significantly higher than those in the limited cutaneous SSc (lcSSc) patients (median [25–75th percentiles], 1693.43 [1086.61–1917.57] vs. 904.55 [714.356–1285.56] pg/mL), while there were no significant differences in the serum LYPD1 levels between lcSSc and healthy controls (904.55 [714.356–1285.56] vs. 750.71 pg/mL [544.00–912.14]). Further analysis revealed that serum LYPD1 levels in patients correlated with skin thickness scores and serum interleukin (IL)-6 levels, which were known to reflect the extent of skin thickening in SSc. Moreover, serum LYPD1 levels showed a decrease with improvement in skin thickness after treatment, along with a decrease in serum IL-6 levels. These results indicate that LYPD1 might be a potential marker for monitoring skin sclerosis and evaluating the efficacy of skin fibrosis treatment in SSc patients.

show abstract

Section: Introductionmentioning

confidence: 98%

Association of serum Ly6/PLAUR domain-containing protein 1 levels with skin sclerosis in systemic sclerosis

Sugimori,

Omori,

Iwasawa

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Regenerative dentistry is an emerging area of dental research, and in recent years, numerous articles have appeared dealing with tooth development, tissue regeneration, organoids, and stem cell differentiation [1][2][3][4][5][6][7][8]. A tooth consists of three mineralized tissues derived from three different tooth germ tissues: enamel organ, dental papilla, and dental follicle.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation

Morsczeck,

De Pellegrin,

Reck

et al. 2023

Biomedicines

View full text Add to dashboard Cite

When research on osteogenic differentiation in dental follicle cells (DFCs) began, projects focused on bone morphogenetic protein (BMP) signaling. The BMP pathway induces the transcription factor DLX3, whichh in turn induces the BMP signaling pathway via a positive feedback mechanism. However, this BMP2/DLX3 signaling pathway only seems to support the early phase of osteogenic differentiation, since simultaneous induction of BMP2 or DLX3 does not further promote differentiation. Recent data showed that inhibition of classical protein kinase C (PKCs) supports the mineralization of DFCs and that osteogenic differentiation is sensitive to changes in signaling pathways, such as protein kinase B (PKB), also known as AKT. Small changes in the lipidome seem to confirm the participation of AKT and PKC in osteogenic differentiation. In addition, metabolic processes, such as fatty acid biosynthesis, oxidative phosphorylation, or glycolysis, are essential for the osteogenic differentiation of DFCs. This review article attempts not only to bring the various factors into a coherent picture of osteogenic differentiation in DFCs, but also to relate them to recent developments in other types of osteogenic progenitor cells.

show abstract

Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways

Hosoya,

Takebe,

Seki-Kishimoto

et al. 2024

Histochem Cell Biol

View full text Add to dashboard Cite

Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development

Cited by 4 publications

References 58 publications

Association of serum Ly6/PLAUR domain-containing protein 1 levels with skin sclerosis in systemic sclerosis

Association of serum Ly6/PLAUR domain-containing protein 1 levels with skin sclerosis in systemic sclerosis

Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation

Polycomb protein Bmi1 promotes odontoblast differentiation by accelerating Wnt and BMP signaling pathways

Contact Info

Product

Resources

About