Identification of gynogenetic Megalobrama amblycephala induced by red crucian carp sperm and establishment of a new hypoxia tolerance strain

Fu, Wen; Chu, Xianbin; Xiao, Weiwei; Shen, Tianyu; Peng, Liangyue; Wang, Yude; Liu, Wenbin; Liu, Jinhui; Luo, Kun; Chen, Bo; Xiao, Yamei; Liu, Shaojun

doi:10.1016/j.aquaculture.2021.737608

Cited by 12 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoxia is a frequent phenomenon in the aquatic environment, causing intermittent hypoxic stress to aquatic organisms . Hypoxic tolerance is the key to fish survival in hypoxic environments . The LOE value is typically used to measure the hypoxia tolerance of fish, where lower values indicate a greater tolerance to hypoxia .…”

Section: Discussionmentioning

confidence: 99%

“…44 Hypoxic tolerance is the key to fish survival in hypoxic environments. 45 The LOE value is typically used to measure the hypoxia tolerance of fish, where lower values indicate a greater tolerance to hypoxia. 46 In this study, we found that the LOE value of largemouth bass exposed to IHE for 4 weeks was significantly lower than that of the normoxia group, showing a stronger ability to tolerate hypoxia in the IHE group.…”

Section: Ihe Improved the Hypoxia Tolerancementioning

confidence: 99%

See 1 more Smart Citation

Exposure to Intermittent Environmental Hypoxia Promotes Vascular Remodeling through Angiogenesis in the Liver of Largemouth Bass (Micropterus salmoides)

Yan

Zhao

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

In this study, we explored the effects of 4 weeks of intermittent hypoxic exposure (IHE) on liver angiogenesis and related regulatory mechanisms in largemouth bass (Micropterus salmoides). The results indicated that the O 2 tension for loss of equilibrium (LOE) decreased from 1.17 to 0.66 mg/L after 4 weeks of IHE. Meanwhile, the red blood cell (RBC) and hemoglobin concentrations significantly increased during IHE. Our investigation also found that the observed increase in angiogenesis was correlated with a high expression of related regulators, such as Jagged, phosphoinositide-3-kinase (PI3K), and mitogen-activated protein kinase (MAPK). After 4 weeks of IHE, the overexpression of factors related to angiogenesis processes mediated by HIF-independent pathways (such as nuclear factor kappa-B (NF-κB), NADPH oxidase 1 (NOX1), and interleukin 8 (IL8)) was correlated with the accumulation of lactic acid (LA) in the liver. The addition of cabozantinib, a specific inhibitor of VEGFR2, blocked the phosphorylation of VEGFR2 and downregulated the expression of downstream angiogenesis regulators in largemouth bass hepatocytes exposed to hypoxia for 4 h. These results suggested that IHE promoted liver vascular remodeling by the regulation of angiogenesis factors, presenting a potential mechanism for the improvement of hypoxia tolerance in largemouth bass.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Ihe Improved the Hypoxia Tolerancementioning

confidence: 99%