Identification of heat shock protein 10 within the equine embryo, endometrium, and maternal peripheral blood mononuclear cells

Hatzel, J.N.; Bouma, Gerrit J.; Cleys, Ellane R.; Bemis, Lynne T.; Ehrhart, E. J.; McCue, Patrick M.

doi:10.1016/j.theriogenology.2014.11.020

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Considering AFP-IV was related to antioxidative, anti-inflammatory and antibacterial functions (Mao et al, 2018), and it upregulated in C. hamatus, the AFP-IV may play an important role in the C. hamatus immune system. Furthermore, in the "response to stress" GO group (Table .1), the presence of MnSOD and hspe1 has been reported to play an important role in antioxidant status, inflammation, transformation and other normal cellular functions (Brannen & Gilmour, 2018;Hatzel et al, 2015;Qin et al, 2020). The protein KRT8 was upregulated in the skin mucus of gilthead sea bream (Sparus aurata), and after chronic exposure to low temperatures many fragments or cleaved proteins presented as keratin forms were detected.…”

Section: Discussionmentioning

confidence: 99%

Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps

Huang

Jia

et al. 2021

Journal of Fish Biology

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The white-blooded Antarctic icefish is the only known vertebrate lacking oxygentransporting haemoglobins. Fish skin mucus, as the first line of defence against pathogens, can reflect fish welfare. In this study, we analysed the skin mucus proteome profiles of the two Antarctic fish species, the white-blooded Antarctic icefish, Chionodraco hamatus, and the red-blooded Antarctic fish, Notothenia coriiceps, unfolding the different proteins by liquid chromatography coupled with tandem mass spectrometry isobaric tags for relative and absolute quantitation (iTRAQ) technology.Of the 4444 totally identified proteins, 227 differentially expressed proteins (DEPs) were found in the comparison between C. hamatus and N. coriiceps, of which 121 were upregulated and 106 were downregulated in the icefish. In the Kyoto Encyclopedia of Genes and Genomes pathway annotation, we found two pathways "Legionellosis" and "Complement and coagulation cascades" were significantly enriched, among of which innate immune candidate proteins such as C3, CASP1, ASC, F3 and C9 were significantly upregulated, suggesting their important roles in C. hamatus immune system. Additionally, the DEP protein-protein interaction network analysis and "Response to stress" GO category provided candidate biomarkers for deep understanding of the distinct immune response of the two Antarctic fish underlying the cold adaptation.

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Section: Discussionmentioning

confidence: 99%

Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps

Huang

Jia

et al. 2021

Journal of Fish Biology

View full text Add to dashboard Cite

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“…In particular a protein called the “early pregnancy factor” (EPF) was first described in mice as an immunosuppressive agent ( Morton et al, 1974 ) and subsequently identified in additional species and humans ( Morton et al, 1982 ; Tinneberg et al, 1984 ). The biological features of EPF suggest an opportunity for early pregnancy diagnosis: it could be, in the future, a marker to verify UPA’s mechanism of action ( Hatzel et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Action of Ulipristal Acetate for Emergency Contraception: A Systematic Review

2016

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Ulipristal acetate (UPA) is now recommended as first choice hormonal emergency contraception (EC), due to its higher efficacy and similar safety compared to Levonorgestrel – EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate. A Medline database search was performed in order to find recent articles related to UPA’s effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo’s attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concurs in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action.

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“…As a result, intracytoplasmic sperm injection is the only viable method for producing equine embryos in vitro , albeit with a substantially lower efficacy than natural breeding. Studies exploring early equine pregnancy have focused on endocrine shifts ( Stout & Allen 2001 a , b , 2002 , Raeside et al 2004 ), embryo and endometrial gene expression ( Klein et al 2010 , Klein & Troedsson 2011 b , Klein 2016 ), protein and receptor profiling ( Zavy et al 1979 , Bazer & Roberts 1983 , Suire et al 2001 , Scholtz et al 2009 , 2014 , Hatzel et al 2015 , Lawson et al 2018 , Smits et al 2018 ), miRNA characterisation ( Grøndahl & Hyttel 1996 ) and attempts to identify a putative MRP factor secreted by the conceptus ( Ohnuma et al 2000 , Klein & Troedsson 2011 a , Swegen et al 2017 ). While these studies have advanced our collective knowledge, recent technical and analytical advancements in the field of lipidomics ( Xu et al 2020 ), including the development of methods to investigate interactions between lipids with proteins and peptides ( Saliba et al 2015 ), open the possibility of new discoveries in equine reproductive physiology.…”

Section: Introductionmentioning

confidence: 99%

Conception and early pregnancy in the mare: lipidomics the unexplored frontier

Lawson

Grupen

Baker

et al. 2022

Reproduction and Fertility

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Lipids are dynamic biological molecules that play key roles in metabolism, inflammation, cell signalling and structure. They are biologically significant in the physiology of conception and reproduction. Many of the mechanisms surrounding equine conception and the early feto-maternal dialogue are yet to be understood at a biochemical level. Recently, lipidomic technologies have advanced considerably, and analytical strategies have been enhanced and diversified. Consequently, in-depth lipidomic exploration now has the potential to reveal new lipid biomarkers and biochemical relationships that improve our understanding of the processes leading to efficient and successful reproduction. This review considers the role of lipids in the various reproductive organs involved in conception, providing new insights into the enigmatic pathways governing early reproductive physiology of the mare.

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Identification of heat shock protein 10 within the equine embryo, endometrium, and maternal peripheral blood mononuclear cells

Cited by 9 publications

References 33 publications

Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps

Specific immunity proteomic profile of the skin mucus of Antarctic fish Chionodraco hamatus and Notothenia coriiceps

Mechanism of Action of Ulipristal Acetate for Emergency Contraception: A Systematic Review

Conception and early pregnancy in the mare: lipidomics the unexplored frontier

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