Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Sana, Ahuja; Malviya, Avneesh

doi:10.4103/jfmpc.jfmpc_941_21

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…In their study, J. Fu et al [14] observed a higher proportion of men, with 45 (60%) male patients and 30 (40%) female patients. Sana, Avneesh, [15] and their colleagues noted that, 105 (70%) were men and 45 (30%) were girls.…”

Section: Discussionmentioning

confidence: 97%

Hematological Parameters for COVID-19 Cases

2024

South Eastern European Journal of Public Health

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Over the past few decades, the Corona virus has emerged as a significant global health concern, leading to severe respiratory illness and long-term health complications. Thoroughly analyzing hematology indices helps medical professionals develop personalized treatment plans and deliver specialized care to patients in critical conditions. Identifying potentially life-threatening complications, such as disseminated intravascular coagulation, early on and intervening effectively can greatly enhance the patient's prognosis. According to a source, there is a reference to a specific point or piece of information. Therefore, the objective of this study was to assess the HT-P and their relationship with the clinical profile, enabling clinicians to determine the severity and prognosis of patients with COVID-19. Therefore, our study has led us to the conclusion that closely monitoring these levels is beneficial for effective patient management. By understanding the relationships between these parameters and clinical profiles, healthcare professionals are able to evaluate the severity and prognosis of individuals with COVID-19 illnesses.

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Section: Discussionmentioning

confidence: 97%

Hematological Parameters for COVID-19 Cases

2024

South Eastern European Journal of Public Health

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“…Pleiotropic outcomes of SARS-CoV-2 infections in iron deficient and iron overloaded mice might be envisaged, given the complexity of iron regulation [20], the modulation of iron biomarkers and homeostasis during SARS-CoV-2 infections [14,[23][24][25][26][27][28][29][30][31], and the robust proinflammatory responses associated with SARS-CoV-2 infections [66,68,116,161]. However, perhaps unexpected was the increase in Th1/Th2 ratios and B cell signatures in both iron deficient and iron load mice.…”

Section: Discussionmentioning

confidence: 99%

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

Carolin,

Frazer,

Yan

et al. 2024

Preprint

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The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of comorbidities. A considerable literature suggests iron deficiency and iron overload may contribute to increased infection, inflammation and disease severity, although direct causal relationships have been difficult to establish. Here we generate iron deficient and iron loaded C57BL/6J mice by feeding low and high iron diets, with mice on a normal iron diet representing controls. All mice were infected with a primary omicron XXB SARS-CoV-2 isolate and lung inflammatory responses were analyzed by histology, immunohistochemistry and RNA-Seq. Compared with controls, iron deficient mice showed no significant changes in lung viral loads or histopathology, whereas, iron loaded mice showed slightly, but significantly, reduced lung viral loads and histopathology. Transcriptional changes were modest, but illustrated widespread dysregulation of inflammation signatures for both iron deficient vs. controls, and iron loaded vs. controls. Some of these changes could be associated with detrimental outcomes, whereas others would be viewed as beneficial. Diet-associated iron deficiency or overload thus induced modest modulations of inflammatory signatures, but no significant histopathologically detectable disease exacerbations.Author summaryA diet deficient in iron can lead to anemia, a widespread problem worldwide. A diet with excessive iron is less common, but can be associated with excessive consumption of iron supplements. We investigate herein using a mouse model, whether low or high iron diets predispose to detrimental outcomes in the lungs after infection with SARS-CoV-2. A considerable literature suggests iron dysregulation would promote infection and inflammation. However, we found, although inflammatory responses showed modest modulations, viral loads were unaffected or slightly reduced, and lung histopathology was either unaffected or indicated slightly less severe disease. These findings do not support a view that low or high iron diets represent comorbidities predisposing to overt detrimental outcomes for acute COVID-19 lung disease.

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“…We described that several clinical parameters such as ferritin, D-dimer, LDH or CRP are good markers between mild and severe patients. Previous reports have also indicated high values of these biomarkers in combination with Absolute Neutrophil Count, Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte ratio (PLR) as biomarkers associated with disease severity [ 31 ]. Moreover, we also found that age is a significant variable, age over 55 is associated with an increased risk of COVID-19 severe cases.…”

Section: Discussionmentioning

confidence: 99%

Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity

Martinez-Diz,

Morales-Álvarez,

Garcia-Iglesias

et al. 2023

Hum Genomics

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Background The use of molecular biomarkers for COVID-19 remains unconclusive. The application of a molecular biomarker in combination with clinical ones that could help classifying aggressive patients in first steps of the disease could help clinician and sanitary system a better management of the disease. Here we characterize the role of ACE2, AR, MX1, ERG, ETV5 and TMPRSS2 for trying a better classification of COVID-19 through knowledge of the disease mechanisms. Methods A total of 329 blood samples were genotyped in ACE2, MX1 and TMPRSS2. RNA analyses were also performed from 258 available samples using quantitative polymerase chain reaction for genes: ERG, ETV5, AR, MX1, ACE2, and TMPRSS2. Moreover, in silico analysis variant effect predictor, ClinVar, IPA, DAVID, GTEx, STRING and miRDB database was also performed. Clinical and demographic data were recruited from all participants following WHO classification criteria. Results We confirm the use of ferritin (p < 0.001), D-dimer (p < 0.010), CRP (p < 0.001) and LDH (p < 0.001) as markers for distinguishing mild and severe cohorts. Expression studies showed that MX1 and AR are significantly higher expressed in mild vs severe patients (p < 0.05). ACE2 and TMPRSS2 are involved in the same molecular process of membrane fusion (p = 4.4 × 10–3), acting as proteases (p = 0.047). Conclusions In addition to the key role of TMPSRSS2, we reported for the first time that higher expression levels of AR are related with a decreased risk of severe COVID-19 disease in females. Moreover, functional analysis demonstrates that ACE2, MX1 and TMPRSS2 are relevant markers in this disease. Graphical abstract

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Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Cited by 6 publications

References 36 publications

Hematological Parameters for COVID-19 Cases

Hematological Parameters for COVID-19 Cases

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity

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