Identification of heterochirality-mediated stereochemical interactions in peptide architectures

Zheng, Yongfang; Mao, Kejing; Chen, Shixian; Zhu, Xinyu; Jiang, Mingyi; Wu, Chang-Jer; Zhu, Hu

doi:10.1016/j.colsurfb.2023.113200

Cited by 2 publications

(2 citation statements)

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“…The Young's modulus of taurine reached 42.9 ± 9.5 GPa, which is far stiffer higher than the ACES (23.7 ± 1.1 GPa) and CHES (19.8 ± 2.8 GPa) crystals. The measured Young's modulus of taurine was compared with the reported amino acids, amino acid derivatives, dipeptides (Figure 3g), [ 11,12,16–18,32–43 ] and its value is significantly higher than most minimalistic molecular biocrystals so far. The calculated point stiffness of taurine, ACES, and CHES crystals (Figure 3d–f; Figure S17, Supporting Information) followed the trend of taurine (454.0 ± 58.1 N m −1 ) > ACES (227.3 ± 7.9 N m −1 ) > CHES (210.2 ± 14.7 N m −1 ), in agreement with the Young's modulus values.…”

Section: Resultsmentioning

confidence: 99%

“…The Young's modulus of taurine reached 42.9 ± 9.5 GPa, which is far stiffer higher than the ACES (23.7 ± 1.1 GPa) and CHES (19.8 ± 2.8 GPa) crystals. The measured Young's modulus of taurine was compared with the reported amino acids, amino acid derivatives, dipeptides (Figure3g),[11,12,[16][17][18][32][33][34][35][36][37][38][39][40][41][42][43] and its value is significantly higher than most minimalistic molecular biocrystals so far. The calculated point stiffness of taurine, ACES, and CHES crystals (Figure3d-f; Figure S17, Supporting Information) followed the trend of taurine (454.0 ± 58.1 N m −1 ) > ACES (227.3 ± 7.9 N m −1 ) > CHES (210.2 ± 14.7 N m −1 ), in agreement with the Young's modulus values.The Young's modulus of the sulfonic acid-containing crystals was further characterized by DFT calculations.…”

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confidence: 99%

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Molecular Engineering of Ordered Piezoelectric Sulfonic Acid‐Containing Assemblies

Yuan,

Cazade,

Zhou

et al. 2023

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Sulfonic acid‐containing bioorganic monomers with wide molecular designability and abundant hydrogen bonding sites hold great potential to design diverse functional biocrystals but have so far not been explored for piezoelectric energy harvesting applications due to the lack of strategies to break the centrosymmetry of their assemblies. Here, a significant molecular packing transformation from centrosymmetric into non‐centrosymmetric conformation by the addition of an amide terminus in the sulfonic acid‐containing bioorganic molecule is demonstrated, allowing a high electromechanical response. The amide‐functionalized molecule self‐assembles into a polar supramolecular parallel β‐sheet‐like structure with a high longitudinal piezoelectric coefficient d11 = 15.9 pm V−1 that produces the maximal open‐circuit voltage of >1 V and the maximal power of 18 nW in nanogenerator devices pioneered. By contrast, molecules containing an amino or a cyclohexyl terminus assemble into highly symmetric 3D hydrogen bonding diamondoid‐like networks or 2D double layer structures that show tunable morphologies, thermostability, and mechanical properties but non‐piezoelectricity. This work not only presents a facile approach to achieving symmetry transformation of bioorganic assemblies but also demonstrates the terminal group and the property correlation for tailor‐made design of high‐performance piezoelectric biomaterials.

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Section: Resultsmentioning

confidence: 99%

“…The Young's modulus of taurine reached 42.9 ± 9.5 GPa, which is far stiffer higher than the ACES (23.7 ± 1.1 GPa) and CHES (19.8 ± 2.8 GPa) crystals. The measured Young's modulus of taurine was compared with the reported amino acids, amino acid derivatives, dipeptides (Figure3g),[11,12,[16][17][18][32][33][34][35][36][37][38][39][40][41][42][43] and its value is significantly higher than most minimalistic molecular biocrystals so far. The calculated point stiffness of taurine, ACES, and CHES crystals (Figure3d-f; Figure S17, Supporting Information) followed the trend of taurine (454.0 ± 58.1 N m −1 ) > ACES (227.3 ± 7.9 N m −1 ) > CHES (210.2 ± 14.7 N m −1 ), in agreement with the Young's modulus values.The Young's modulus of the sulfonic acid-containing crystals was further characterized by DFT calculations.…”

mentioning

confidence: 99%