Identification of High-Risk Brugada Syndrome Patients by Combined Analysis of Late Potential and T-Wave Amplitude Variability on Ambulatory Electrocardiograms

Yoshioka, Koichiro; Amino, Mari; Zaręba, Wojciech; Shima, Makiyoshi; Matsuzaki, Akinobu; Fujii, Toshiharu; Kanda, Shigenobu; Deguchi, Yoshiaki; Kobayashi, Yoshinori; Ikari, Yuji; Kodama, Itsuo; Tanabe, T.

doi:10.1253/circj.cj-12-0932

Cited by 46 publications

(36 citation statements)

References 31 publications

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“…These parameters reflect disorders in ventricular depolarization and repolarization, respectively. 56 In agreement with these findings, a multicenter prospective registry identified fragmentation of the QRS (defined as ≥2 spikes within the QRS complex in leads V1-V3) as a predictor of arrhythmic events in BrS patients without a history of pVT/VF. 57 However, so far none of the above has proven effective in risk prediction.…”

Section: Noninvasive Instrumental Featuressupporting

confidence: 53%

The Brugada Syndrome　― From Gene to Therapy ―

Curcio

Santarpia

Indolfi

2017

Circ J

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It is almost a quarter of century that a pioneering work of 2 researchers named Brugada brought the entire scientific community to understanding the molecular, clinical, and electrophysiological aspects of a distinctive syndrome. It affects mainly young adults with syncope and/or sudden cardiac death caused by polymorphic ventricular tachycardia or ventricular fibrillation in the absence of any sign of cardiac degeneration or alteration. Although the involvement of the epicardial layer of the right ventricular outflow tract, and the requirement of pharmacologic challenge for unveiling concealed forms, have been fully characterized, many areas of uncertainties remain to be elucidated, such as the unpredictable usefulness of programmed ventricular stimulation, the role of radiofrequency catheter ablation for reducing ST-segment elevation, and the value of risk stratification in patients diagnosed with upper displacement of right precordial leads. How much Brugada syndrome is an intense field of research is witnessed by 4 different consensus committees that took place in a relatively short period of time considering the recent discovery of this intricate arrhythmogenic disease. The main focus of this review is to describe the milestones in Brugada syndrome from its first phenotypic and genotypic appraisals to recent achievements in electrical therapies proposed for the management of this fascinating rhythm disturbance that, despite new diagnostic and therapeutic learnings, still predisposes to sudden cardiac death.

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Section: Noninvasive Instrumental Featuressupporting

confidence: 53%

The Brugada Syndrome　― From Gene to Therapy ―

Curcio

Santarpia

Indolfi

2017

Circ J

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“…A previous study reported that the occurrence of LP showed diurnal variations in healthy subjects. 15 The circadian periodicity of LP was also observed in patients with the Brugada syndrome, 10 and the highest prevalence of LP was recognized at midnight. 10 The reason for LP variability may be explained not only by autonomic nervous activity but also by electrolyte abnormalities, body temperature, drug 16 or food intake, 17 or postural changes.…”

Section: Day-night Variations In Lp Incidencementioning

confidence: 91%

“…15 The circadian periodicity of LP was also observed in patients with the Brugada syndrome, 10 and the highest prevalence of LP was recognized at midnight. 10 The reason for LP variability may be explained not only by autonomic nervous activity but also by electrolyte abnormalities, body temperature, drug 16 or food intake, 17 or postural changes. 18 One analysis showed that the mortality rate of 112 sudden deaths in patients with SDB was significantly higher from midnight to 6:00 than that during the day.…”

Section: Day-night Variations In Lp Incidencementioning

confidence: 91%

Arrhythmogenic Substrates in Sleep-Disordered Breathing with Arterial Hypertension

Amino

Yoshioka

Aoki

et al. 2016

Pacing and Clinical Electrophysiology

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“…12,18,19 Interestingly, TAV had no day/night periodicity and was constantly higher in patients with Brugada syndrome with VA (46.6 µV) as compared with asymptomatic patients and healthy controls (35.5 µV). 13 Conversely, TAV was increased during the day only in patients with long QT syndrome (34 µV 2 vs. 25 µV 2 in controls). 18 In order to exclude day/night periodicity effects we propose to record individual ECG at the same point in daytime.…”

Section: Change In T-var and Prediction Of Fast Vamentioning

confidence: 95%

“…Currently, available T-var data, especially in non-ischemic patients and in patients with preserved LVEF, are limited. 12, 13 We hypothesized that T-var is elevated in patients at risk of fast, potentially fatal VA. The objective of this prospective study was to evaluate the clinical value of T-var assessment at multiple time points for the prediction of fast VA.…”

mentioning

confidence: 99%