2019
DOI: 10.3892/ol.2019.11004
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Identification of hub genes and key pathways associated with the progression of gynecological cancer

Abstract: Gynecological cancer is the leading cause of cancer mortality in women. However, the mechanisms underlying gynecological cancer progression have remained largely unclear. In the present study, 799 dysregulated genes were identified in ovarian serous cystadenocarcinoma (OV), 488 dysregulated genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), and 621 dysregulated genes in uterine corpus endometrial carcinoma (UCEC). Bioinformatics analysis revealed that mRNA splicing and cell proli… Show more

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Cited by 38 publications
(30 citation statements)
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“…As shown in the previous studies, Inhibition of FUTs including FUT11 signi cantly decreased the expression and activity of ERK1/2 and p38 MAPK pathway, as well as the progression of human invasive ductal carcinoma [24]. FUT11 was highly expressed in gynecological cancer, and higher expression of FUT11 in patient predicted poor outcome [25]. However, the effects of the FUT11 on proliferation and metastasis have not yet been clearly de ned in human PC cells.…”
Section: Discussionmentioning
confidence: 88%
“…As shown in the previous studies, Inhibition of FUTs including FUT11 signi cantly decreased the expression and activity of ERK1/2 and p38 MAPK pathway, as well as the progression of human invasive ductal carcinoma [24]. FUT11 was highly expressed in gynecological cancer, and higher expression of FUT11 in patient predicted poor outcome [25]. However, the effects of the FUT11 on proliferation and metastasis have not yet been clearly de ned in human PC cells.…”
Section: Discussionmentioning
confidence: 88%
“…Elovl3 knockout mice suffer severely from hair loss and have an imbalance in the lipid species of the sebum 34,35 ; and mouse knockout studies of ELOVL5 / ELOVL6 suggest associations with hepatic steatosis 13 and obesity-induced insulin resistance 14 . ELOVL7, the most recently discovered ELOVL elongase, is associated with prostate 15,16 and gynaecological 17 cancer and early onset Parkinson’s disease 18 . ELOVL7 knockdown reduces cell death and membrane permeabilization during necroptosis, a form of programmed cell death 19 .…”
Section: Discussionmentioning
confidence: 99%
“…Mutations in ELOVL elongases cause severe genetic diseases including Stargardt syndrome 10 and spinocerebellar ataxia 11,12 . Mouse knockouts suggest ELOVL involvement in hepatic steatosis 13 and insulin resistance 14 , and in particular ELOVL7 is implicated in cancer [15][16][17] , early-onset Parkinson's disease 18 and necroptosis 19 . However, very little is known about the molecular mechanisms underlying this key step in fatty acid and lipid synthesis by the ELOVLs.…”
mentioning
confidence: 99%
“…There have also been a lot of contradictory data about the role of EMP1, epithelial membrane protein 1 (summarized in [37]); nevertheless, anti-migratory function of EMP1 in nasopharyngeal cancer cells [38] and its downregulation upon oral dysplasia progression to oral squamous cell carcinoma [39] have been documented; in addition, the mechanism for anti-lymphangiogenic effect of EMP1 through downregulation of VEGFC expression was proposed [38]. Epiregulin (EREG) considered as a hub gene in squamous cervical carcinoma and other gynecological tumors [40] has been reported to undergo silencing in certain types of carcinoma [41]. A plausible explanation for this discrepancy may lie in the multifaceted role of genes like EMP1 and EREG: in addition to angiogenesis, they are involved in a variety of immune reactions, including regulation of T cell chemotaxis and activation and inflammation, as well as in ECM-cell interactions and ECM remodeling, and epithelial differentiation.…”
Section: Differential Gene Expression Analysismentioning
confidence: 99%