Identification of hub genes to regulate breast cancer metastasis to brain by bioinformatics analyses

Tang, Dongyang; Zhao, Xin; Zhang, Li; Wang, Zhiwei; Wang, Cheng

doi:10.1002/jcb.28228

Cited by 70 publications

(49 citation statements)

References 32 publications

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“…Similarly, it has been reported that high SKA3 expression promotes lung cancer cell proliferation and predicts patient outcomes. Through bioinformatics analysis, Tang et al found that SKA3 is associated with elevated susceptibility to breast cancer brain metastasis and negatively correlates with breast cancer survival (75). Our data further validate the correlation between high SKA3 expression and advanced clinical features of G3/G4.…”

Section: Discussionsupporting

confidence: 81%

Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment

et al. 2020

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The role of spindle and kinetochore-associated (SKA) genes in tumorigenesis and cancer progression has been widely studied. However, so far, the oncogenic involvement of SKA family genes in pancreatic cancer and their prognostic potential remain unknown. Methods: Here, we carried out a meta-analysis of the differential expression of SKA genes in normal and tumor tissue. Univariate and multivariate survival analyses were done to evaluate the correlation between SKA family gene expression and pancreas ductal adenocarcinoma (PDAC) prognosis. Joint-effect and stratified survival analysis as well as nomogram analysis were used to estimate the prognostic value of genes. The underlying regulatory and biological mechanisms were identified by Gene set enrichment analysis. Interaction between SKA prognosis-related genes and immune cell infiltration was assessed using the Tumor Immune Estimation Resource tool. Results: We find that SKA1-3 are highly expressed in PDAC tissues relative to noncancer tissues. Survival analysis revealed that high expression of SKA1 and SKA3 independently indicate poor prognosis but they are not associated with relapsefree survival. The prognostic value of SKA1 and SKA3 was further confirmed by the nomogram, joint-effect, and stratified survival analysis. Analysis of underlying mechanisms reveals that these genes influence cancer-related signaling pathways, kinases, miRNA, and E2F family genes. Notably, prognosis-related genes are inversely correlated with several immune cells infiltrating levels. Conclusion: We find that SKA1 and SKA3 expression correlates with prognosis and immune cell infiltration in PDAC, highlighting their potential as pancreatic cancer prognostic biomarkers.

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Section: Discussionsupporting

confidence: 81%

Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment

et al. 2020

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“…The application of bioinformatics methods has identified multiple genes including protein coding genes and non-coding genes associated with cancer progression. 14,15 Numerous miRNAs have been shown to be abnormally expressed in CRC. For instance, expression of miR-483-3p was reported to be downregulated in oxaliplatin-resistant CRC cell lines; it regulates cell migration and apoptosis by targeting FAM171B.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: miR-4324 functions as a tumor suppressor in colorectal cancer by targeting HOXB2

Zhu

Xing

et al. 2019

J Int Med Res

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Objective MicroRNAs (miRNAs) are reported to have crucial roles in human cancers; however, their role in colorectal cancer (CRC) remains largely unknown. Methods In this study, we analyzed the expression of miR-4324 in CRC cell lines using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We also examined miR-4324 expression in CRC tumor tissues using a miRNA expression dataset obtained from the Gene Expression Omnibus. We validated the connection between miR-4324 and homeobox B2 (HOXB2) using a luciferase activity reporter assay and western blotting. The effects of miR-4324 and HOXB2 on CRC cell malignant behaviors in vitro were further investigated. Results miR-4324 expression was significantly decreased in both CRC tumor tissues and cell lines. Overexpression of miR-4324 suppressed CRC cell proliferation, migration, and invasion. In contrast, overexpression of HOXB2 promoted CRC malignant cell behaviors. Furthermore, we validated HOXB2 as a direct target of miR-4324. Conclusions miR-4324 expression was decreased in CRC. miR-4324 regulates CRC cell proliferation, migration, and invasion by targeting HOXB2.

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“…Knockdown of SKA3 expression activates the spindle assembly checkpoint with loss of sister chromatid cohesion, leading to mitotic arrest during metaphase 12 , 13 . SKA3 is implicated in the development and progress of lung adenocarcinoma, prostate cancer, cervical cancer, and breast cancer 14 – 17 . Here, we show that SKA3 is also highly expressed in LSCC, and higher levels of SKA3 are closely associated with poorer clinicopathological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

et al. 2020

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Spindle and kinetochore-associated complex subunit 3 (SKA3) is a well-known regulator of chromosome separation and cell division, which plays an important role in cell proliferation. However, the mechanism of SKA3 regulating tumor proliferation via reprogramming metabolism is unknown. Here, SKA3 is identified as an oncogene in laryngeal squamous cell carcinoma (LSCC), and high levels of SKA3 are closely associated with malignant progression and poor prognosis. In vitro and in vivo experiments demonstrate that SKA3 promotes LSCC cell proliferation and chemoresistance through a novel role of reprogramming glycolytic metabolism. Further studies reveal the downstream mechanisms of SKA3, which can bind and stabilize polo-like kinase 1 (PLK1) protein via suppressing ubiquitin-mediated degradation. The accumulation of PLK1 activates AKT and thus upregulates glycolytic enzymes HK2, PFKFB3, and PDK1, resulting in enhancement of glycolysis. Furthermore, our data reveal that phosphorylation at Thr360 of SKA3 is critical for its binding to PLK1 and the increase in glycolysis. Collectively, the novel oncogenic signal axis “SKA3-PLK1-AKT” plays a critical role in the glycolysis of LSCC. SKA3 may serve as a prognostic biomarker and therapeutic target, providing a potential strategy for proliferation inhibition and chemosensitization in tumors, especially for LSCC patients with PLK1 inhibitor resistance.

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Identification of hub genes to regulate breast cancer metastasis to brain by bioinformatics analyses

Cited by 70 publications

References 32 publications

Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment

Identification of Spindle and Kinetochore-Associated Family Genes as Therapeutic Targets and Prognostic Biomarkers in Pancreas Ductal Adenocarcinoma Microenvironment

RETRACTED: miR-4324 functions as a tumor suppressor in colorectal cancer by targeting HOXB2

Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

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