Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

Ribas, María de los Ángeles; Tejero, Yahisel; Cordero, Yanislet; Pérez, Daileny; Sausy, Aurélie; Hübschen, Judith M.

doi:10.1002/jmv.25444

Cited by 14 publications

(24 citation statements)

References 16 publications

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“…Nevertheless, the identification of ancient B19V in a Colonial context is noteworthy considering several recent reports reveal that measles-like cases were actually attributable to B19V (De Los Ángeles Ribas et al, 2019;Rezaei et al, 2016) or rubella (Anderson et al, 1985;Davidkin et al, 1998;De Los Ángeles Ribas et al, 2019;Rezaei et al, 2016), which produce a similar kind of rash and fever.…”

Section: Discussionmentioning

confidence: 95%

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

Guzmán-Solís

Villa-Islas

Bravo-Lopez

et al. 2021

eLife

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After the European colonization of the Americas there was a dramatic population collapse of the Indigenous inhabitants caused in part by the introduction of new pathogens. Although there is much speculation on the etiology of the Colonial epidemics, direct evidence for the presence of specific viruses during the Colonial era is lacking. To uncover the diversity of viral pathogens during this period, we designed an enrichment assay targeting ancient DNA (aDNA) from viruses of clinical importance and applied it to DNA extracts from individuals found in a Colonial hospital and a Colonial chapel (16th c. - 18th c.) where records suggest victims of epidemics were buried during important outbreaks in Mexico City. This allowed us to reconstruct three ancient human parvovirus B19 genomes, and one ancient human hepatitis B virus genome from distinct individuals. The viral genomes are similar to African strains, consistent with the inferred morphological and genetic African ancestry of the hosts as well as with the isotopic analysis of the human remains, suggesting an origin on the African continent. This study provides direct molecular evidence of ancient viruses being transported to the Americas during the transatlantic slave trade and their subsequent introduction to New Spain. Altogether, our observations enrich the discussion about the etiology of infectious diseases during the Colonial period in Mexico.

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Section: Discussionmentioning

confidence: 95%

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

Guzmán-Solís

Villa-Islas

Bravo-Lopez

et al. 2021

eLife

View full text Add to dashboard Cite

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“…1 Erythema infectiosum is often mistakenly diagnosed as measles or rubella. [2][3][4] In Belarus, during the final stages of measles and rubella elimination between 2009 and 2011, 26.2% of suspected measles or rubella cases were B19V-positive compared with 6.1% for measles and 2.6% for rubella. 2 In Cuba, where measles and rubella had been eliminated, B19V infection was confirmed in 10.7% of patients with fever-rash illness and none were diagnosed with measles or rubella.…”

Section: Introductionmentioning

confidence: 99%

Contribution of parvovirus B19 in suspected cases of measles/rubella in Osaka, Japan, between 2011 and 2021

Kaida

Kanbayashi

Kurata

et al. 2023

Journal of Medical Virology

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Erythema infectiosum, caused by human parvovirus B19 (B19V), is difficult to diagnose by its clinical symptoms and is often misdiagnosed as measles or rubella. Timely confirmation of measles/rubella or other viral etiologies via laboratory tests can provide an accurate picture of the infection status, which can appropriate response. The purpose of this study was to determine the contribution of B19V as an etiological agent for fever‐rash in suspected cases of measles and rubella in Osaka Prefecture between 2011 and 2021. Of 1356 suspected cases, 167 were confirmed with measles and 166 with rubella using nucleic acid testing (NAT). Of the remaining 1023 cases, 970 from which blood specimens could be obtained were screened by real‐time polymerase chain reaction for B19V, from which 136 (14%) tested positive. Of the positives cases, 21% were young children (9 years and younger), while 64% were adults (20 years and older). Phylogenetic tree analysis showed that 93 samples belonged to genotype 1a. The importance of B19V in the etiology of fever‐rash illness was revealed in this study. The importance of laboratory diagnosis by NAT in maintaining the status of measles elimination and to eliminate rubella was reaffirmed.

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“…This study included in the non-rubella panel, sera collected from confirmed cases of other viral agents that may present with symptoms similar to that of rubella (fever and rash). Sera from these cases may be subjected to rubella IgM testing as part of the differential diagnosis strategy or captured through case finding algorithms (7,8,(11)(12)(13)(14)(15). The Serion ELISA method in particular was prone to cross-reactivity with sera from cases of dengue, measles and parvovirus B19.…”

Section: Discussionmentioning

confidence: 99%

“…A panel of 238 sera was assembled that included in the non-rubella panel, sera IgM positive for chikungunya, dengue, measles, parvovirus B19, roseola and zika viruses. These viruses were chosen because they can also present with fever and rash symptoms and thus may be captured in rubella testing algorithms during differential diagnosis or active case finding (7,8,(11)(12)(13)(14)(15). Some, such as parvovirus B19, have been previously noted to be a source of cross-reactivity with methods for the detection of anti-rubella IgM antibody (16).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Rubella Virus-Specific IgM Antibodies

et al. 2022

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Rubella and congenital rubella syndrome are caused by the rubella virus and are preventable through vaccination, making disease eradication possible. Monitoring of progress towards global eradication and local elimination requires high quality, sensitive disease surveillance that includes laboratory confirmation of cases. Previous evaluations of anti-rubella IgM detection methods resulted in the broad adoption of Enzygnost (most recently manufactured by Siemens) enzyme-linked immunosorbent assay (ELISA or EIA) kits within WHO’s global measles and rubella laboratory network but they have been discontinued. This study evaluates seven comparable ELISA methods from six manufacturers (Trinity Biotech, Euroimmun, Clin-Tech, NovaTec and Virion\Serion) as well as one automated chemiluminescent assay (CLIA) from Diasorin. These methods consisted of three IgM capture methods and five indirect ELISA methods. A panel of 238 sera was used for the evaluation that included 38 archival rubella IgM positive sera and 200 sera collected from symptomatically similar cases, such as measles, dengue, parvovirus B19 and roseola. With this panel of sera, the sensitivity of the methods ranged from 63.2% to 100% and the specificity from 80.0% to 99.5%. No single method had both sensitivity and specificity >90%, unless sera with equivocal results were considered to be presumptive positive. Some methods, particularly the Serion ELISA, had a large number of false positives with parvovirus B19 IgM positive sera as well as sera from confirmed measles cases. The performance characteristics identified in this evaluation serve as a reminder to not rely solely on rubella IgM results for case confirmation in elimination settings.

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Identification of human parvovirus B19 among measles and rubella suspected patients from Cuba

Cited by 14 publications

References 16 publications

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

Contribution of parvovirus B19 in suspected cases of measles/rubella in Osaka, Japan, between 2011 and 2021

Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Rubella Virus-Specific IgM Antibodies

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