Identification of Hylemonella gracilis as an Antagonist of Yersinia pestis Persistence

Pawlowski, David R.; Raslawsky, Amy; Siebert, Gretchen; Metzger, Daniel

doi:10.4172/2157-2526.s3-004

Cited by 5 publications

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“…Consistent with our microbiome-mediated protection hypothesis, we identified Hylemonella gracilis as part of the facial skin core, which has been shown to prevent long term colonization by Yersinia pestis [ 74 ]. Other beneficial bacteria present in both gut and facial skin microbiomes include Lactobacillus sakei , an antilisterial bacterium [ 75 ].…”

Section: Discussionsupporting

confidence: 71%

Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging

et al. 2018

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BackgroundVultures have adapted the remarkable ability to feed on carcasses that may contain microorganisms that would be pathogenic to most other animals. The holobiont concept suggests that the genetic basis of such adaptation may not only lie within their genomes, but additionally in their associated microbes. To explore this, we generated shotgun DNA sequencing datasets of the facial skin and large intestine microbiomes of the black vulture (Coragyps atratus) and the turkey vulture (Cathartes aura). We characterized the functional potential and taxonomic diversity of their microbiomes, the potential pathogenic challenges confronted by vultures, and the microbial taxa and genes that could play a protective role on the facial skin and in the gut.ResultsWe found microbial taxa and genes involved in diseases, such as dermatitis and pneumonia (more abundant on the facial skin), and gas gangrene and food poisoning (more abundant in the gut). Interestingly, we found taxa and functions with potential for playing beneficial roles, such as antilisterial bacteria in the gut, and genes for the production of antiparasitics and insecticides on the facial skin. Based on the identified phages, we suggest that phages aid in the control and possibly elimination, as in phage therapy, of microbes reported as pathogenic to a variety of species. Interestingly, we identified Adineta vaga in the gut, an invertebrate that feeds on dead bacteria and protozoans, suggesting a defensive predatory mechanism. Finally, we suggest a colonization resistance role through biofilm formation played by Fusobacteria and Clostridia in the gut.ConclusionsOur results highlight the importance of complementing genomic analyses with metagenomics in order to obtain a clearer understanding of the host-microbial alliance and show the importance of microbiome-mediated health protection for adaptation to extreme diets, such as scavenging.Electronic supplementary materialThe online version of this article (10.1186/s13028-018-0415-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 71%

Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging

et al. 2018

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“…This bacterium passed a 0.1-μm filter, which suggests a very small cell size, theoretically justifying referring to these bacteria as ultrasmall bacteria ( 26 ). However, against our expectation, the microscopic analysis revealed that this bacterium is not ultrasmall in cell size but possesses a very thin diameter and showed the typical spiraled morphology known for these species ( 38 – 41 ). These observations are in line with previous research by Wang et al ( 42 ) showing that H. gracilis can pass through filters of various pore sizes ranging from 0.45 μm to 0.1 μm, most probably thanks to their cell shape and cell morphology.…”

Section: Discussioncontrasting

confidence: 64%

Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis

et al. 2023

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“…Consistent with our microbiome-mediated protection hypothesis, we identified Hylemonella gracilis as part of the facial core, which has shown to prevent long term colonization by Yersinia pestis [71]. Other beneficial bacteria present in both gut and facial microbiomes include Lactobacillus sakei , an antilisterial bacteria [72].…”

Section: Discussionsupporting

confidence: 54%

Protective role of the vulture facial and gut microbiomes aid adaptation to scavenging

Mendoza

Graves

Roggenbuck

et al. 2017

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Identification of Hylemonella gracilis as an Antagonist of Yersinia pestis Persistence

Cited by 5 publications

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Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging

Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging

Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis

Protective role of the vulture facial and gut microbiomes aid adaptation to scavenging

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