Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Orhan, Nilüfer; Aslan, Mustafa; Pekcan, Mert; Orhan, Didem Deliorman; Bedir, Erdal; Ergün, Fatma

doi:10.1016/j.jep.2011.10.027

Cited by 37 publications

(21 citation statements)

References 29 publications

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“…MDA is an important end product of lipid peroxidation; thus, MDA, so MDA measurement is an important index that shows lipid peroxidation. Previous studies showed increased MDA levels in the liver and kidney of diabetes-induced rats [70,71]. In our study, the MDA level was markedly higher in the diabetic group compared with the control group.…”

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confidence: 59%

Endothelin Receptor Inhibition with Bosentan Delays Onset of Liver Injury in Streptozotocin-Induced Diabetic Condition

et al. 2014

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These data provide clear evidence that bosentan treatment is associated with promising hepatoprotective effect against diabetes-induced liver damage via reduction of cell inflammation and oxidative damage. These data suggest that ET receptors may be an important actor in diabetes-related liver damage, and blockage of these receptors may become a target for preventing diabetic complications in the future.

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confidence: 59%

Endothelin Receptor Inhibition with Bosentan Delays Onset of Liver Injury in Streptozotocin-Induced Diabetic Condition

et al. 2014

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“…3,[56][57][58][59] However, no scientific studies are reported on the antioxidant properties of wood extracts obtained from J. foetidissima and O. europaea var. 3,[56][57][58][59] However, no scientific studies are reported on the antioxidant properties of wood extracts obtained from J. foetidissima and O. europaea var.…”

Section: Antioxidant Capacitymentioning

confidence: 99%

DNA protection, antioxidant, antibacterial and enzyme inhibition activities of heartwood and sapwood extracts from juniper and olive woods

et al. 2015

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In this study, DNA protective, antioxidant, antibacterial and enzyme inhibiting properties of methanol extracts obtained from juniper and olive heartwood and sapwood were determined. These extracts were tested by five antioxidant methods (DPPH scavenging, FRAP, CUPRAC, metal chelating and phosphomolybdenum). Generally, heartwood extracts of both species are more efficient for DPPH radical scavenging activity, cupric ion reducing activity, ferric reducing antioxidant power and metal chelating activity than sapwood extracts. When compared to heartwood extracts, sapwood extracts have larger inhibition zone in disk diffusion test. In addition, all extracts showed high antibacterial activity against Staphylococcus aureus. DNA protection of both extracts had a capacity to inhibit the DNA damage arisen from Fenton's reagent. The highest DNA protective activity was observed in juniper sapwood extract with 84%. Furthermore, other extracts also indicated more than 60% of DNA protective activity. Olive wood extracts displayed the strongest enzyme inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Although juniper heartwood extracts showed highest anti-amylase, anti-glucosidase and anti-tyrosinase effects, they had no ability for inhibition BChE.The methanol extracts of olive samples demonstrated the most antioxidant activity (DPPH, CUPRAC and FRAP). In addition, juniper samples showed the highest anti-amylase, anti-tyrosinase, metal chelating and DNA protective activity. According to these results, the extracts of juniper and olive wood can be considered as a source of natural bio active agents for dietary, pharmacological and medicinal applications. This research will also serve as a base for future studies about biological activities of wood extracts.

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“…This study pointed out treatment of diabetic rats with Joso fruit and leaf crude extracts decreased blood glucose levels and lipid peroxidation in tissues remarkably (Orhan et al, 2011). The active constituents of Joso berries were isolated as shikimic acid, 4-O-␤-D-glucopyranosyl ferulic acid and oleuropeic acid-8-O-␤-D-glucopyranoside and their mechanism of action were also discussed in our recent study (Orhan et al, 2012).…”

Section: Discussionmentioning

confidence: 76%

A bioactivity guided study on the antidiabetic activity of Juniperus oxycedrus subsp. oxycedrus L. leaves

Orhan

Aslan

Demirci

et al. 2012

Journal of Ethnopharmacology

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Identification of hypoglycaemic compounds from berries of Juniperus oxycedrus subsp. oxycedrus through bioactivity guided isolation technique

Cited by 37 publications

References 29 publications

Endothelin Receptor Inhibition with Bosentan Delays Onset of Liver Injury in Streptozotocin-Induced Diabetic Condition

Endothelin Receptor Inhibition with Bosentan Delays Onset of Liver Injury in Streptozotocin-Induced Diabetic Condition

DNA protection, antioxidant, antibacterial and enzyme inhibition activities of heartwood and sapwood extracts from juniper and olive woods

A bioactivity guided study on the antidiabetic activity of Juniperus oxycedrus subsp. oxycedrus L. leaves

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