Identification of Immune-Related Prognostic Markers in Gastric Cancer

He, Yanxin; Song, Haiping; Jiang, Yanfang; Ren, Weina

doi:10.1155/2022/7897274

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…[36] In gastric cancer, OGN has also been reported to cause differences in immune cell infiltration and immune function between the tumor group and the control group. [37] Research reports that OGN can be considered as a key candidate marker gene for EC, [29] which is basically consistent with our research results. However, it is not clear how it relates to immune infiltration in EC, whether it can affect the progress of EC by regulating immune cell infiltration, and how it can affect the progress of EC, which is worthy of in-depth study.…”

Section: Discussionsupporting

confidence: 92%

Analysis of the characteristics of immune infiltration in endometrial carcinoma and its relationship with prognosis based on bioinformatics

Liu

Lin

et al. 2023

Medicine

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To explore immune-related molecules that affect the prognosis of endometrial carcinoma (EC) using bioinformatic data mining. The expression data related to EC were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. After differential expression analysis, the intersection with immune related genes in the ImmPort database was used to obtain immune related differentially expressed genes (IRDEGs). The correlation between clinicopathological information and the prognosis of IRDEGs was further analyzed to obtain prognosis related differentially expressed immune genes (PRDEIG). Gene correlation analysis and Gene Set Enrichment Analysis (GSEA) enrichment analysis showed that PRDEIG was enriched in cancer-related functional pathways. We then analyzed the relationship between PRDEIG and immune cell infiltration, and further analyzed the mRNA and protein expression of PRDEIG in EC using TCGA and the human protein expression atlas (THPA) databases. After the intersection of the differential expression analysis results and immune-related genes, 4 IRDEGs were obtained: osteoglycin (OGN), LTBP4, CXCL12, and SPP1. After analyzing the relationship between 4 IRDEGs and clinicopathological parameters and prognosis of patients with EC, revealed that only OGN was not only related to tumor immunity, but also affected the prognosis of patients with EC. Gene correlation and GSEA enrichment of OGN were analyzed. The results showed that OGN was significantly enriched in 6 functional pathways: epithelial mesenchymal transition, KRAS signaling up, myogenesis, UV response, allograft rejection and apical junction. In addition, it was also found that OGN was significantly correlated with a variety of immune cells. The results of TCGA and THPA database showed that the mRNA and protein expression levels of OGN decreased in EC. OGN may affect the epithelial mesenchymal transformation (EMT) of tumor by affecting the infiltration of tumor immune cells.

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Section: Discussionsupporting

confidence: 92%

Analysis of the characteristics of immune infiltration in endometrial carcinoma and its relationship with prognosis based on bioinformatics

Liu

Lin

et al. 2023

Medicine

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“…A number of previous studies have explored the immune microenvironment of gastric cancer through TCGA and GEO databases, showing a similar trend to our results, which validate our CyTOF data well (43,44). Other studies identified several prognosis-related genes and further constructed a prognostic model of gastric cancer patients based on public databases (45)(46)(47)(48)(49). Elucidating the detailed mechanism underlying the tumor-specific immune landscape of GC remains a future challenge to be tackled in the fields of tumor biology and immunology.…”

Section: Discussionsupporting

confidence: 88%

Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression

et al. 2022

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The profiling of the tumor immune microenvironment (TIME) is critical for guiding immunotherapy strategies. However, how the composition of the immune landscape affects the tumor progression of gastric cancer (GC) is ill-defined. Here, we used mass cytometry to perform simultaneous in-depth immune profiling of the tumor, adjacent tissues, and blood cells from GC patients and revealed a unique GC tumor-immune signature, where CD8+ T cells were present at a lower frequency in tumor tissues compared to adjacent tissues, whereas regulatory T cells and tumor-associated macrophages (TAMs) were significantly increased, indicating strong suppressive TIME in GC. Incorporated with oncogenic genomic traits, we found that the unique immunophenotype was interactively shaped by a specific GC gene signature across tumor progression. Earlier-stage GC lesions with IFN signaling enrichment harbored significantly altered T-cell compartments while advanced GC featured by metabolism signaling activation was accumulated by TAMs. Interestingly, PD-1 expression on CD8+ T cells was relatively higher in earlier-stage GC patients, indicating that these patients may derive more benefits from PD-1 inhibitors. The dynamic properties of diverse immune cell types revealed by our study provide new dimensions to the immune landscape of GC and facilitate the development of novel immunotherapy strategies for GC patients.

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“…STAD tumors thrive within a complex tumor microenvironment that aids in promoting malignant tumor progression and evading immune defenses [ 27 , 28 ]. Recent breakthroughs in immunotherapy have uncovered the potential of targeting immune regulatory cells or immune checkpoint factors within the tumor microenvironment to elicit anti-tumor immune responses [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Disulfidptosis-related lncRNA signature reveals immune microenvironment and novel molecular subtyping of stomach adenocarcinoma

Li,

Xia,

Song

et al. 2024

Heliyon

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Identification of Immune-Related Prognostic Markers in Gastric Cancer

Cited by 13 publications

References 23 publications

Analysis of the characteristics of immune infiltration in endometrial carcinoma and its relationship with prognosis based on bioinformatics

Analysis of the characteristics of immune infiltration in endometrial carcinoma and its relationship with prognosis based on bioinformatics

Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression

Disulfidptosis-related lncRNA signature reveals immune microenvironment and novel molecular subtyping of stomach adenocarcinoma

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