2022
DOI: 10.3390/ph15050605
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Identification of Immune Subtypes of Esophageal Adenocarcinoma to Predict Prognosis and Immunotherapy Response

Abstract: A low response rate limits the application of immune checkpoint inhibitors (ICIs) in the treatment of esophageal adenocarcinoma (EAC), which requires the precise characterization of heterogeneous tumor microenvironments. This study aimed to identify the molecular features and tumor microenvironment compositions of EAC to facilitate patient stratification and provide novel strategies to improve clinical outcomes. Here, we performed consensus molecular subtyping with nonnegative matrix factorization (NMF) using … Show more

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“…There exist, however, certain challenges associated with spatial and temporal disparities of PD-L1 expression in GEJ adenocarcinoma [8], and the therapeutic effect of tislelizumab combined with chemotherapy in GEJ adenocarcinoma is still murky for the inconsistent results [9,10].…”
Section: Introductionmentioning
confidence: 99%
“…There exist, however, certain challenges associated with spatial and temporal disparities of PD-L1 expression in GEJ adenocarcinoma [8], and the therapeutic effect of tislelizumab combined with chemotherapy in GEJ adenocarcinoma is still murky for the inconsistent results [9,10].…”
Section: Introductionmentioning
confidence: 99%