Identification of infection by Leishmania spp. in wild and domestic animals in Brazil: a systematic review with meta-analysis (2001–2021)

Ratzlaff, Fabiana Raquel; Osmari, Vanessa; Silva, Daniele da; Vasconcellos, Jaíne Soares de Paula; Pötter, Luciana; Fernandes, Fagner D’ambroso; Filho, José Américo de Mello; Botton, Sônia de Ávila; Vogel, Fernanda Silveira Flôres; Sangioni, Luís Antônio

doi:10.1007/s00436-023-07862-y

Cited by 6 publications

(4 citation statements)

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“…In a study performed by Osmari (2023), the author confirmed the presence of three species of vectors of importance for public and animal health, being the first report of the presence of L. longipalpis (Osmari et al, 2022), which is considered the primary vector of VL in Brazil by the Ministry of Health. In addition, P. fischeri and M. migonei are also implicated as transmitters of the visceral and mucocutaneous form of the disease (Rêgo et al, 2020).…”

Section: Introductionmentioning

confidence: 84%

“…Domestic birds, such as chickens ( Gallus gallus domesticus ), turkeys ( Meleagris gallopavo ), geese ( Anser anser ) and guinea fowl ( Numida meleagris) are globally distributed animals that are raised and kept in peridomestic spaces, such as backyards, both in urban and rural areas. These birds keep close contact with humans and various domestic animals, such as dogs ( Canis familiaris ) and cats ( Felis catus ), wild predators like foxes ( Dusicyon vetulus and Cerdocyon thous ) and marsupials ( Didelphis albiventris and Didelphis marsupialis), and synanthropic animals such as murines ( Rattus rattus) ( Sherlock, 1996 ; Alexander et al, 2002 ; Ratzlaff et al, 2023 ) and chiropterans, which some studies found infected by some Leishmania species, indicating that bats may participate in the biological cycle of Leishmania spp. and act as a host, reservoir, and/or source of infection ( Savani et al, 2010 ; Shapiro et al, 2013 ; Ratzlaff et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Detection of anti-Leishmania spp. antibodies in poultry from central region of Rio Grande do Sul, Brazil

Tatto,

Fernandes,

Costa

et al. 2023

Rev. Bras. Parasitol. Vet.

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Domestic birds such as Gallus gallus, Meleagris gallopavo, Anser anser and Numida meleagris are widely distributed throughout the world and maintain contact with humans and other animal species considered reservoirs of both Visceral Leishmaniasis (VL) and American Tegumentary Leishmaniasis (ATL), including dogs and cats; wild canids, marsupials; and synanthropic animals such as rodents and chiroptera. Therefore, this study aimed to detect the presence of anti-Leishmania spp. antibodies in birds from a rural area of the municipality of Santa Maria, southern Brazil. From May to December 2022, 262 blood samples were collected from 244 chickens, 8 turkeys, 7 guinea fowl and 3 geese, distributed in 27 rural properties in 6 districts. All the sites visited presented positive birds for the presence of Leishmania spp. Thus, it is inferred that, contact with this protozoan can induce the production of antibodies, suggesting that these animals can be used as sentinels for the circulation of this agent. In addition, the blood of these animals is a preferred food source for insects of the subfamily Phlebotominae, which can be used them as bioindicators of the presence of these phlebotomes.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Detection of anti-Leishmania spp. antibodies in poultry from central region of Rio Grande do Sul, Brazil

Tatto,

Fernandes,

Costa

et al. 2023

Rev. Bras. Parasitol. Vet.

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“…? ], which mainly affects mammals and is transmitted through the bite of infected female sandflies [2][3][4][5][6].…”

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The Future of Leishmaniasis Treatment: Protein Targets and Beyond

Padilla,

Álvarez,

Campo

et al. 2023

Preprint

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This review summarizes up-to-date research on Leishmania protein structures, extracted primarily from the Protein Data Bank (PDB), that are involved in metabolic pathways of the parasite causing \textit{Leishmania}. Additionally, we examine current advancements in identifying and developing bioactive chemical agents to treat this largely neglected tropical disease. We examined experimental data from \textit{in vitro}, \textit{in vivo}, or \textit{in silico} sources, classifying the information into four categories: a) vector taxonomy and geographical distribution; b) parasite taxonomy and geographical distribution; c) enzymatic functions of proteins involved in parasite/host interactions across developmental stages (e.g. oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and cytokines); and d) standard and experimental treatments using bioactive chemical compounds. Our goal is to provide a reference framework for research focused on elucidating interaction mechanisms and ligand-protein activation/inactivation processes related specifically to \textit{Leishmania} infections. We therefore highlight enzymes known to participate in biochemical pathways triggered during Leishmania infection episodes. This review summarizes current knowledge to inform and guide future discovery efforts targeting proteins and pathways for improved \textit{Leishmania} disease management.

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“…[1][2][3][4] These diseases predominantly affect mammals and are transmitted via the bites of infected female sandflies. [5][6][7][8][9] The World Health Organization (WHO) classifies leishmaniasis as a Neglected Tropical Disease (NTD) due to the limited availability of effective treatments and insufficient investment in research and development. [3,[10][11][12][13] Consequently, instances of the predominant forms of leishmaniasis -cutaneous (CL) and visceral (VL) -continue to escalate globally.…”

mentioning

confidence: 99%

The Future of Leishmaniasis Treatment: Protein Targets and Beyond

Padilla,

Álvarez,

Campo

et al. 2023

Preprint

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This review presents an updated overview of research concerning Leishmania protein structures, primarily sourced from the Protein Data Bank (PDB), that play a role in the metabolic pathways of the Leishmania parasite. Furthermore, we assess the current progress in the identification and development of bioactive chemical agents aimed at addressing this substantially overlooked tropical disease. We have analyzed experimental data obtained from in vitro, in vivo and in silico sources. This data has been categorized into four main areas: a) vector taxonomy and geographic distribution; b) parasite taxonomy and geographic distribution; c) enzymatic functions of proteins engaged in parasite/host interactions throughout various developmental stages (such as oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and cytokines); and d) established and experimental treatments employing bioactive chemical compounds. Our objective is to establish a foundational point of reference for research efforts concentrating on the elucidation of interaction mechanisms and the processes of ligand-protein activation/inactivation, specifically linked to Leishmania infections. Consequently, we emphasize enzymes recognized for their involvement in the biochemical pathways incited during Leishmania infection episodes. This review encapsulates the current understanding, offering insights to inform and direct future explorations aimed at targeting proteins and pathways to enhance the management of Leishmania-related diseases.

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Identification of infection by Leishmania spp. in wild and domestic animals in Brazil: a systematic review with meta-analysis (2001–2021)

Cited by 6 publications

References 91 publications

Detection of anti-Leishmania spp. antibodies in poultry from central region of Rio Grande do Sul, Brazil

Detection of anti-Leishmania spp. antibodies in poultry from central region of Rio Grande do Sul, Brazil

The Future of Leishmaniasis Treatment: Protein Targets and Beyond

The Future of Leishmaniasis Treatment: Protein Targets and Beyond

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