Identification of infectious organisms in cytopathology: A review of ancillary diagnostic techniques

Allison, Derek B.; Simner, Patricia J.; Ali, Syed Z.

doi:10.1002/cncy.22023

Cited by 15 publications

(9 citation statements)

References 34 publications

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“…1,2 Hyphae also branch dichotomously, in acute angles of approximately 45 , in an arborizing pattern. 1,2 An accompanying necrotic and inflammatory background can usually be observed. 1 In some cases, hyphae may become tangled and distorted, causing difficulty in identification and diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Calcium oxalate crystals in pulmonary aspergillosis

Pereira,

Cristóvão,

Dvindenko

et al. 2024

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

Calcium oxalate crystals in pulmonary aspergillosis

Pereira,

Cristóvão,

Dvindenko

et al. 2024

Diagnostic Cytopathology

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“…There are many advantages to utilizing cytology samples as an adjunct to routine microbiology laboratory methods. For example, cytology samples can be obtained by non-invasive and minimally invasive techniques, and interpretation is affordable, accurate, and fast [30].…”

Section: Cytologymentioning

confidence: 99%

“…Routine cytology stains, including the PAP stains, can adequately identify a number of microorganisms. In general, the PAP stain provides a high-quality view of nuclear and cytoplasmic detail, making it an ideal stain for assessing a host's response to an infectious agent, such as viruses and bacteria [30].…”

Section: Cytologymentioning

confidence: 99%

The value of PAP and AgNOR techniques in identification of bacterial infections and Cytomorphological changes in sputum of Sudanese pango Smokers

Idris

Okasha

2022

Microbes and Infectious Diseases

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Background:Sputum cytology" is an example of exfoliative cytology, which is based on shedding of cells derived from the lining of an organ into a cavity from where they can be removed by non-invasive means. Aim:The study aimed to assess the value of PAP and AgNOR techniques in identification of bacterial infections and cytomorphological changes in sputum of Sudanese pango smokers.Methods:In this study 200 apparently healthy individuals volunteers were selected, of which 100 were pango smoker (cases) and 100 were non-pango users (control), Pap smear and AgNOR was used for the staining of sputum smears. All quality control measures were adopted during specimen collection and processing and diagnosis. Statistical Package for Social sciences (SPSS) software version 16 was used for data entry and analysis.Results: Findings demonstrated that the inflammation, indicated by presence of inflammatory cells was detected in 36/88among case group , most of them was chronic type, while only 5/100 had inflammation among non-smokers with significant relation , the p value is (0.000).The presence of infectious agent was illustrated among pango smokers most of them was bacterial and Actinomyces with significant relation the p value was (0.01). The nuclear atypia was reported among 5 out of 88 of heavy smoker's atypia. While no case of atypia was reported among non-smokers the p value is (0.217). Conclusions: Pango smoking is a major risk for occurrence of cellular changes that induce the prolifrative activity that increase the risk factor of lung cancer.

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“…Various cytology specimens can be used for screening and diagnosis of infectious diseases and these include exfoliative cytology samples and fine‐needle aspiration (FNA) material. Advances in molecular diagnostics, such as human papillomavirus (HPV) testing using liquid‐based cytology samples, has led to an increasing menu of diagnostic tests for micro‐organism identification in cytology samples 3 . This review article is focused on application of molecular diagnostic testing in commonly sampled cytology materials, including gynecologic specimens, cerebrospinal fluid (CSF), bronchoalveolar lavage (BAL), and urine samples, for diagnosis of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

Molecular diagnostics of infectious disease: Detection and characterization of microbial agents in cytology samples

Caruso

Yang

2022

Diagnostic Cytopathology

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Background Cytology samples are widely used to diagnose various infectious diseases by detection and identification of causative infectious agents, including bacteria, fungi, and viruses. The role of cytopathology in infectious disease has expanded tremendously in the past decades with the advances in molecular techniques. Molecular diagnostic methods, compared to conventional methods, have shown improved patient outcome, reduction in cost, and shortened hospital stay times. The aim of this article is to review molecular testing in cytology samples for diagnosis of infectious diseases. Methods The literature search for molecular testing in common cytology samples for diagnosis of infectious diseases was performed. The findings of the studies were summarized. The common cytology samples included in this article were gynecologic specimens, cerebrospinal fluid, bronchoalveolar lavage, and urine samples. Conclusions There are a number of molecular diagnostic tests that are available to be used in common cytology samples to detect infectious agents. Each test has its own advantages and limitations. It is our hope that upon reading this review article, the readers will have better understanding of molecular diagnostic testing of infectious diseases utilizing commonly sampled cytology specimens in daily practice.

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Identification of infectious organisms in cytopathology: A review of ancillary diagnostic techniques

Cited by 15 publications

References 34 publications

Calcium oxalate crystals in pulmonary aspergillosis

Calcium oxalate crystals in pulmonary aspergillosis

The value of PAP and AgNOR techniques in identification of bacterial infections and Cytomorphological changes in sputum of Sudanese pango Smokers

Molecular diagnostics of infectious disease: Detection and characterization of microbial agents in cytology samples

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