Identification of key genes and regulatory networks involved in the Comorbidity of atrial fibrillation and chronic obstructive pulmonary disease

Xiong, Shan; Liu, Qiming; Zhou, Shenghua; Xiao, Yichao

doi:10.1016/j.heliyon.2023.e22430

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22430

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Identification of key genes and regulatory networks involved in the Comorbidity of atrial fibrillation and chronic obstructive pulmonary disease

Shan Xiong,

Qiming Liu,

Shenghua Zhou

et al.

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2024

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Cited by 1 publication

References 62 publications

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The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure

Draper,

Huang,

Pande

et al. 2024

FEBS Letters

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Heart failure (HF) is highly prevalent. Mechanisms underlying HF remain incompletely understood. Splicing factors (SF), which control pre‐mRNA alternative splicing, regulate cardiac structure and function. This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein‐L (hnRNPL) in the failing heart. hnRNPL protein increased in left ventricular tissue from mice with transaortic constriction‐induced HF and from HF patients. In left ventricular tissue, hnRNPL was detected predominantly in nuclei. Knockdown of the hnRNPL homolog Smooth in Drosophila induced cardiomyopathy. Computational analysis of predicted mouse and human hnRNPL binding sites suggested hnRNPL‐mediated alternative splicing of tropomyosin, which was confirmed in C2C12 myoblasts. These findings identify hnRNPL as a sensor of cardiac dysfunction and suggest that disturbances of hnRNPL affect alternative splicing in HF.

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The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure

Draper,

Huang,

Pande

et al. 2024

FEBS Letters

View full text Add to dashboard Cite

show abstract

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Identification of key genes and regulatory networks involved in the Comorbidity of atrial fibrillation and chronic obstructive pulmonary disease

Cited by 1 publication

References 62 publications

The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure

The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure

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