Identification of key genes and signaling pathways in regulatory T cells with the knockout of IL23R

Abstract

IL-23R has been found to contribute to susceptibility to cancer such as leukemia. However, the mechanism of IL23R in Regulatory T cells (Tregs) of cancers is still unknown. Here, our objective is to identify the key molecules, biological processes, and signaling pathways by analyzing the RNA-seq data. The GSE197287 was created by the Illumina HiSeq 4000 (Mus musculus). The gene enrichment analyses showed that autophagy and yersinia infection are the main signaling pathways in the Tregs with the knockout of IL23R. In addition, we identified the top ten interactive molecules including CDK1, POLR2A, FN1, MAPK8, CUL3, BARD1, TPX2, TRAF6, DTL, and MCM5. This study may benefit the clinical work of the treatment of leukemia.