Identification of key tumorigenesis‑related genes and their microRNAs in colon cancer

Xie, Binbin; Zhao, Rongjie; Bai, Bingjun; Wu, Yahong; Xu, Yuzi; Si, Lu; Fang, Yong; Wang, Zhanggui; Maswikiti, Ewetse Paul; Zhou, Xin; Pan, Hongming; Han, Weidong

doi:10.3892/or.2018.6726

Cited by 23 publications

(23 citation statements)

References 33 publications

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“…Due to high rate of colorectal cancer-related deaths worldwide [14, 15], the miRNA profile in biopsies and serum has been extensively studied for this condition [16–20] but the lack of more comprehensive studies in both tissue and serum from the same patients and the repeatability for the identified miRNAs in different conditions is needed. Therefore, the goal of our study was to investigate the populations of miRNAs expressed in colorectal cancerous tissue when compared with a healthy adjacent tissue and serum from the same patients, to determine potential new biomarkers for early detection, prediction of patient recovery and future more personalized therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA regulation in colorectal cancer tissue and serum

et al. 2019

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Colorectal cancer is recognized as the fourth leading cause of cancer-related deaths worldwide. Thus, there is ongoing search for potential new biomarkers allowing quicker and less invasive detection of the disease and prediction of the treatment outcome. Therefore, the aim of our study was to identify colorectal cancer specific miRNAs expressed in cancerous and healthy tissue from the same patient and to further correlate the presence of the same miRNAs in the circulation as potential biomarkers for diagnosis. In the current study we detected a set of 40 miRNAs differentially regulated in tumor tissue when comparing with healthy tissue. Additionally, we found 8 miRNAs differentially regulated in serum of colorectal cancer patients. Interestingly, there was no overlap in miRNAs regulated in tissue and serum, suggesting that serum regulated miRNAs may be not actively secreted from colorectal tumor cells. However, four of differentially expressed miRNAs, including miR-21, miR-17, miR-20a and miR-32 represent the miRNAs characteristic for different tumor types, including breast, colon, lung, pancreas, prostate and stomach cancer. This finding suggests important groups of miRNAs which can be further validated as markers for diagnosis of tumor tissue and regulation of carcinogenesis.

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Section: Introductionmentioning

confidence: 99%

MicroRNA regulation in colorectal cancer tissue and serum

et al. 2019

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“…In contrast, the expression of other TRP channels appears to be decreased in cancer. For instance, TRPC4 channels in renal carcinoma (Veliceasa et al, 2007), TRPM6 in colorectal tumors (Xie et al, 2018), TRPV4 in skin and bladder tumor cells (Fusi et al, 2014;Mizuno et al, 2014;Yu et al, 2019) or the TRPV6 in lung carcinomas (Fan et al, 2014). In conclusion, the TRP channels superfamily expression levels have been described to be either up or down regulated in different tumors ( Table 1).…”

Section: Trp Calcium Permeable Channelsmentioning

confidence: 93%

“…Gene downregulation (Xie et al, 2018;Anderson et al, 2019) TRPM7 Breast, pancreas, ovarian, gastric and colorectal…”

Section: ) Trpm6 Colorectalmentioning

confidence: 99%

Calcium Permeable Channels in Cancer Hallmarks

Tajada¹,

Villalobos²

2020

Front. Pharmacol.

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Cancer, the second cause of death worldwide, is characterized by several common criteria, known as the "cancer hallmarks" such as unrestrained cell proliferation, cell death resistance, angiogenesis, invasion and metastasis. Calcium permeable channels are proteins present in external and internal biological membranes, diffusing Ca 2+ ions down their electrochemical gradient. Numerous physiological functions are mediated by calcium channels, ranging from intracellular calcium homeostasis to sensory transduction. Consequently, calcium channels play important roles in human physiology and it is not a surprise the increasing number of evidences connecting calcium channels disorders with tumor cells growth, survival and migration. Multiple studies suggest that calcium signals are augmented in various cancer cell types, contributing to cancer hallmarks. This review focuses in the role of calcium permeable channels signaling in cancer with special attention to the mechanisms behind the remodeling of the calcium signals. Transient Receptor Potential (TRP) channels and Store Operated Channels (SOC) are the main extracellular Ca 2+ source in the plasma membrane of nonexcitable cells, while inositol trisphosphate receptors (IP 3 R) are the main channels releasing Ca 2+ from the endoplasmic reticulum (ER). Alterations in the function and/or expression of these calcium channels, as wells as, the calcium buffering by mitochondria affect intracellular calcium homeostasis and signaling, contributing to the transformation of normal cells into their tumor counterparts. Several compounds reported to counteract several cancer hallmarks also modulate the activity and/or the expression of these channels including non-steroidal anti-inflammatory drugs (NSAIDs) like sulindac and aspirin, and inhibitors of polyamine biosynthesis, like difluoromethylornithine (DFMO). The possible role of the calcium permeable channels targeted by these compounds in cancer and their action mechanism will be discussed also in the review.

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“…On these bases, TRPM6 and TRPM7 could be potential players in CRC. Indeed, it was reported that TRPM6 is downregulated in CRC tissues on mRNA level [120,123], and its higher expression is correlated with an increased overall survival [123]. On the other hand, TRPM7 was suggested to be upregulated in CRC on mRNA level [151].…”

Section: Colorectal Cancermentioning

confidence: 99%

TRP Channels in Digestive Tract Cancers

Stokłosa

Borgström

Kappel

et al. 2020

IJMS

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

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Identification of key tumorigenesis‑related genes and their microRNAs in colon cancer

Cited by 23 publications

References 33 publications

MicroRNA regulation in colorectal cancer tissue and serum

MicroRNA regulation in colorectal cancer tissue and serum

Calcium Permeable Channels in Cancer Hallmarks

TRP Channels in Digestive Tract Cancers

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