Identification of kukoamines as the novel markers for quality assessment of Lycii Cortex

Li, Yuanyuan; Rui, Di; Baibado, Joewel Tarra; Cheng, Yu-Shan; Huang, Yi‐Hui Christine; Sun, Hongyan; Cheung, Hon-Yeung

doi:10.1016/j.foodres.2013.11.008

Cited by 21 publications

(14 citation statements)

References 24 publications

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“…1, although extract of LyC was composed of arrays of compounds, they can be generally classified into three major groups: 1) coumarins; 2) dihydrocaffeic conjugates; 3) cyclic-peptides containing tryptophan fragments, according to the UV spectra of natural products reported in literatures (EI-Seedi, Zahra, Goransson, & Verpoorte, 2007;Funayama et al, 1995;Kayser & Kolodziej, 1995;Li et al, 2014;Potterat, 2010). LC-MS/MS analysis further revealed the molecular weights and structures of compounds that showed relative high abundance in each group (Fig.…”

Section: Investigation On Phytochemical Composition Of Lycmentioning

confidence: 94%

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

Huang

et al. 2015

Journal of Functional Foods

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Section: Investigation On Phytochemical Composition Of Lycmentioning

confidence: 94%

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

Huang

et al. 2015

Journal of Functional Foods

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“…Lycii Cortex, the root bark of Lycium chinens is a famous traditional Chinese herb and a functional food widely consumed in health-preserving cuisines. [249] Thus, from this Chinese medicinal plant was isolated the active compound, a bis(dihydrocaffeoyl) spermine derivative namely kukoamine A 139 and later it was also encountered from the potato Solanum tuberosum (Figure 42). [248,250] Few synthetic pathways were reported in literature to achieve the synthesis of kukoamine A 139, using either a selective alkylation of spermine or a solid-phase chemistry.…”

Section: Vi-1-kukoamine Amentioning

confidence: 99%

Synthesis and Biological Activities of Naturally Functionalized Polyamines: An Overview

Negrel

Brunel

2021

CMC

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“…Lycii Cortex (LyC) is an herb frequently prescribed in TCM to treat chronic metabolic diseases, e.g., diabetes and hypertension (Li et al, 2004; Potterat, 2009; Su et al, 2013), yet the mechanism has never been revealed. Our previous study revealed that kukoamines, especially kukoamine B, are the major compounds of LyC, accounting for approximately 2% of the herbal dry mass (Li et al, 2014). Recent research from our group and other research groups has revealed that KB (or its isomer kukoamine A) has bioactivities in anti-oxidation, anti-inflammation, and anti-insulin resistance (Liu et al, 2011; Li et al, 2015, 2017), which are highly associated with diabetes; however, direct in vivo evidence showing the beneficial effect of KB on T2DM from the viewpoint of metabolomics has not yet been found.…”

Section: Introductionmentioning

confidence: 99%

A Metabolomics Approach to Investigate Kukoamine B—A Potent Natural Product With Anti-diabetic Properties

Stewart

Ye³

et al. 2019

Front. Pharmacol.

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Due to the surge in type 2 diabetes mellitus (T2DM), treatments for chronic metabolic dysregulations with fewer side-effects are sought. Lycii Cortex (LyC), a traditional Chinese Medicine (TCM) herb has a long history of being widely prescribed to treat T2DM as alternative medicine; however, the bioactive molecules and working mechanism remained unknown. Previous studies revealed kukoamine B (KB) as a major and featured compound for LyC with bioactivities for anti-oxidation and acute inflammation, which may be related to anti-diabetes properties. This study aims to understand the efficacy and the mode of action of KB in the diabetic (db/db) mouse model using a metabolomics approach. Parallel comparison was conducted using the first-line anti-diabetic drugs, metformin and rosligtazone, as positive controls. The db/db mice were treated with KB (50 mg kg−1 day−1) for 9 weeks. Bodyweight and fasting blood glucose were monitored every 5 and 7 days, respectively. Metabolomics and high-throughput molecular approaches, including lipidomics, targeted metabolomics (Biocrates p180), and cytokine profiling were applied to measure the alteration of serum metabolites and inflammatory biomarkers between different treatments vs. control (db/db mice treated with vehicle). After 9 weeks of treatment, KB lowered blood glucose, without the adverse effects of bodyweight gain and hepatomegaly shown after rosiglitazone treatment. Lipidomics analysis revealed that KB reduced levels of circulating triglycerides, cholesterol, phosphatidylethanolamine, and increased levels of phosphatidylcholines. KB also increased acylcarnitines, and reduced systemic inflammation (cytokine array). Pathway analysis suggested that KB may regulate nuclear transcription factors (e.g., NF-κB and/or PPAR) to reduce inflammation and facilitate a shift toward metabolic and inflammatory homeostasis. Comparison of KB with first-line drugs suggests that rosiglitazone may over-regulate lipid metabolism and anti-inflammatory responses, which may be associated with adverse side effects, while metformin had less impact on lipid and anti-inflammation profiles. Our research from holistic and systemic views supports the conclusion that KB is the bioactive compound of LyC for managing T2DM, and suggests KB as a nutraceutical or a pharmaceutical candidate for T2D treatment. In addition, our research provides insights related to metformin and rosiglitazone action, beyond lowering blood glucose.

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Identification of kukoamines as the novel markers for quality assessment of Lycii Cortex

Cited by 21 publications

References 24 publications

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

Preventing H2O2-induced toxicity in primary cerebellar granule neurons via activating the PI3-K/Akt/GSK3β pathway by kukoamine from Lycii Cortex

Synthesis and Biological Activities of Naturally Functionalized Polyamines: An Overview

A Metabolomics Approach to Investigate Kukoamine B—A Potent Natural Product With Anti-diabetic Properties

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