Identification of Lichen Substances

Huneck, Siegfried; Yoshimura, Isao

doi:10.1007/978-3-642-85243-5

Cited by 492 publications

(324 citation statements)

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“…They have the remarkable ability to tolerate adverse atmospheric condition. Another peculiarity of lichen is the presence of secondary metabolites such as depsides and dibenzofuran (Asahina and Shibata 1954;Culberson 1969;Huneck and Yoshimura 1996), so called lichen substances (Fig. 1).…”

Section: Unique Characteristics and Chemical Composition Of Lichensmentioning

confidence: 99%

Lichens as a potential natural source of bioactive compounds: a review

2010

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Biological activity of material whether known in folk medicine or observed in planned screening program has been the starting point in the drug research. The general pattern is the isolation of active principles, elucidation their structures, followed by attempts for modulation of its activity potential by chemical modification. Lichens are valuable plant resources and are used as medicine, food, fodder, perfume, spice, dyes and for miscellaneous purposes throughout the world. Lichens are well known for the diversity of secondary metabolites that they produce. Compounds isolated from various lichen species have been reported to display diverse biological activities.Here we review the medicinal efficacy of lichen substances, which intends to explore the pharmaceutical potential of lichen substances.

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Section: Unique Characteristics and Chemical Composition Of Lichensmentioning

confidence: 99%

Lichens as a potential natural source of bioactive compounds: a review

2010

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“…Life under these conditions correlates with the production of a variety of compound classes. Several of these are already found in plants or in other fungi, but about 80% reach highest diversity in lichens (Huneck and Yoshimura 1996). The valuation of these metabolites for medicinal purposes is generating an increasing interest as their activities are varied and sometimes significant.…”

Section: Introductionmentioning

confidence: 99%

Bioactive lichen metabolites: alpine habitats as an untapped source

2010

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International audienceLichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites. Some of these are forming an available biomass for phytochemical investigations, including the assessment of biological activities of the isolated compounds. The alpine or polar region are characterised by highly stressful environmental conditions for many organisms, but lichens are among the dominating organisms in these habitats. In the performant mutual protective system, lichen fungi often accumulate high amounts of metabolites with specific physicochemical properties (UV absorbents, hydrophobicity) which help the lichens to survive. Unique secondary metabolites and polysaccharides have been isolated and tested from these organisms. Even though this has been tested until now only with a low number of compounds so far, interesting activities have been recorded. We review here some of the antimicrobial, anti-inflammatory, antiproliferative and antioxidant activities properties described. Solutions with axenic biotechnological cultivation of each symbiotic partner and particularly the mycobiont to obtain the lichen secondary metabolites are challenging to overcome the limitations for the supply of these rare compounds. Additionally, these lichens appear to harbour a diversity of culturable microorganisms from which active compounds have also been isolated recently

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“…(+) Usnic acid (1) was isolated from a mixture of lichens Usnea, [α] D 25 +441 (c 0.016, CHCl 3 ); 20 the physicochemical characteristics of the sample corresponded to published data. 21 The UV spectra were not informative; IR spectra showed only an increase in the band intensities at 1069, 1118, and 1292 cm -1 and a very pronounced increase in the band intensi ties at 141 and 1187 cm -1 , caused by the appearance of C-F vibrations.…”

Section: Methodsmentioning

confidence: 97%