Identification of LncRNA CASC7/ miR-26/ASPN/TGF-β/Smad Axis in Endometrial Cancer

Zhang, Xiajun; Yang, Jie; Zhou, Wenjun; Chen, Zhenshi; Wu, Weidong; Zhang, Shaoru; Wei, Lihui

doi:10.17582/journal.pjz/20211201051249

Cited by 3 publications

(1 citation statement)

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“…Zhang et al found that ASPN expression was higher in normal endometrial tissue compared to EC tissue. Additionally, the authors speculate that lncRNA CASC7 inhibits miR-26, inhibits ASPN, inhibits TGF-β, and promotes XIAP, to activate the SMAD/XIAP pathway in EC, thus improving survival and the invasiveness of endometrial cancer cells [ 33 ] PRELP protein may function as a molecule anchoring basement membranes to the underlying connective tissue [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women

Takenaka

Curry‐Hyde

Olzomer

et al. 2022

IJMS

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Endometrial cancer is the most common gynaecological malignancy in developed countries. One of the largest risk factors for endometrial cancer is obesity. The aim of this study was to determine whether there are differences in the transcriptome of endometrial cancers from obese vs. lean women. Here we investigate the transcriptome of endometrial cancer between obese and lean postmenopausal women using rRNA-depleted RNA-Seq data from endometrial cancer tissues and matched adjacent non-cancerous endometrial tissues. Differential expression analysis identified 12,484 genes (6370 up-regulated and 6114 down-regulated) in endometrial cancer tissues from obese women, and 6219 genes (3196 up-regulated and 3023 down-regulated) in endometrial cancer tissues from lean women (adjusted p-value < 0.1). A gene ontology enrichment analysis revealed that the top 1000 up-regulated genes (by adjusted p-value) were enriched for growth and proliferation pathways while the top 1000 down-regulated genes were enriched for cytoskeleton restructure networks in both obese and lean endometrial cancer tissues. In this study, we also show perturbations in the expression of protein coding genes (HIST1H2BL, HIST1H3F, HIST1H2BH, HIST1H1B, TTK, PTCHD1, ASPN, PRELP, and CDH13) and the lncRNA MBNL1-AS1 in endometrial cancer tissues. Overall, this study has identified gene expression changes that are similar and also unique to endometrial cancers from obese vs. lean women. Furthermore, some of these genes may serve as prognostic biomarkers or, possibly, therapeutic targets for endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women

Takenaka

Curry‐Hyde

Olzomer

et al. 2022

IJMS

View full text Add to dashboard Cite

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Epigenetic regulation of TGF-β pathway and its role in radiation response

Ding,

Zhou,

2024

International Journal of Radiation Biology

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Interplay between LncRNA/miRNA and TGF-β Signaling in the Tumorigenesis of Gynecological Cancer

Safavi,

Moghadam,

Haghighi

et al. 2024

CPD

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Gynecologic cancers are among the most common malignancies with aggressive features and poor prognosis. Tumorigenesis in gynecologic cancers is a complicated process that is influenced by multiple factors, including genetic mutations that activate various oncogenic signaling pathways, including the TGF-β pathway. Aberrant activation of TGF-β signaling is correlated with tumor recurrence and metastasis. It has been shown that non-coding RNAs (ncRNAs) have crucial effects on cancer cell proliferation, migration, and metastasis. Upregulation of various ncRNAs, including long non-coding RNAs (lncRNA) and microRNAs (miRNAs), has been reported in several tumors, like cervical, ovarian, and endometrial cancers, but their cellular mechanisms remain to be investigated. Thus, recognizing the role of ncRNAs in regulating the TGF-β pathway may provide novel strategies for better treatment of cancer patients. The present study summarizes recent findings on the role of ncRNAs in regulating the TGF-β signaling involved in tumor progression and metastasis in gynecologic cancers.

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Identification of LncRNA CASC7/ miR-26/ASPN/TGF-β/Smad Axis in Endometrial Cancer

Abstract: Authors' Contribution MI and MR collected the samples. MI compliled the data. JK supervised the research and wrote the manuscript. ZR peformed statistical analysis. MI, MR and KK presented methodology.

Cited by 3 publications

References 0 publications

Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women

Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women

Epigenetic regulation of TGF-β pathway and its role in radiation response

Interplay between LncRNA/miRNA and TGF-β Signaling in the Tumorigenesis of Gynecological Cancer

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