Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

Gao, Guangyu; Shi, Xinya; Yao, Zhen; Shen, Jiaofeng; Shen, Liqin

doi:10.1097/md.0000000000022105

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Furthermore, supplementation with APE up-regulated three signaling pathways in CAM cells, namely, the NOD-like receptor signaling pathway, the PPAR signaling pathway, and the FoxO signaling pathway (Table S4). The NOD receptor signaling pathway is involved in cellular processes such as survival, proliferation, and activation . It has been found that the PPAR signaling pathway could participate in the myocyte proliferation process .…”

Section: Resultsmentioning

confidence: 99%

“…The NOD receptor signaling pathway is involved in cellular processes such as survival, proliferation, and activation. 45 It has been found that the PPAR signaling pathway could participate in the myocyte proliferation process. 46 The downstream signaling pathway of cell proliferation, the FoxO signaling pathway, also plays an important role in regulating cell proliferation, cell cycle, and oxidative stress.…”

Section: Proteomics Analysismentioning

confidence: 99%

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Integrated Omics Approach: Revealing the Mechanism of Auxenochlorella pyrenoidosa Protein Extract Replacing Fetal Bovine Serum for Fish Muscle Cell Culture

Dong,

Jiang,

Chang

et al. 2024

J. Agric. Food Chem.

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The process of producing cell-cultured meat involves utilizing a significant amount of culture medium, including fetal bovine serum (FBS), which represents a considerable portion of production expense while also raising environmental and safety concerns. This study demonstrated that supplementation with Auxenochlorella pyrenoidosa protein extract (APE) under low-serum conditions substantially increased Carassius auratus muscle (CAM) cell proliferation and heightened the expression of Myf5 compared to the absence of APE. An integrated intracellular metabolomics and proteomics analysis revealed a total of 13 and 67 differentially expressed metabolites and proteins, respectively, after supplementation with APE in the medium containing 5%FBS, modulating specific metabolism and signaling pathways, which explained the application of APE for passage cell culture under lowserum conditions. Further analysis revealed that the bioactive factors in the APE were protein components. Moreover, CAM cells cultured in reconstructed serum-free media containing APE, L-ascorbic acid, insulin, transferrin, selenium, and ethanolamine exhibited significantly accelerated growth in a scale-up culture. These findings suggest a promising alternative to FBS for fish muscle cell culture that can help reduce production costs and environmental impact in the production of cultured meat.

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Section: Resultsmentioning

confidence: 99%

Section: Proteomics Analysismentioning

confidence: 99%

Integrated Omics Approach: Revealing the Mechanism of Auxenochlorella pyrenoidosa Protein Extract Replacing Fetal Bovine Serum for Fish Muscle Cell Culture

Dong,

Jiang,

Chang

et al. 2024

J. Agric. Food Chem.

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miRNAs as biomarkers breast cancer and their influence on tumor epigenetics

Davey,

Miller

2024

Epigenetics in Human Disease

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Detecting Blood Methylation Signatures in Response to Childhood Cancer Radiotherapy via Machine Learning Methods

Guo

Ding

et al. 2022

Biology

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Radiotherapy is a helpful treatment for cancer, but it can also potentially cause changes in many molecules, resulting in adverse effects. Among these changes, the occurrence of abnormal DNA methylation patterns has alarmed scientists. To explore the influence of region-specific radiotherapy on blood DNA methylation, we designed a computational workflow by using machine learning methods that can identify crucial methylation alterations related to treatment exposure. Irrelevant methylation features from the DNA methylation profiles of 2052 childhood cancer survivors were excluded via the Boruta method, and the remaining features were ranked using the minimum redundancy maximum relevance method to generate feature lists. These feature lists were then fed into the incremental feature selection method, which uses a combination of deep forest, k-nearest neighbor, random forest, and decision tree to find the most important methylation signatures and build the best classifiers and classification rules. Several methylation signatures and rules have been discovered and confirmed, allowing for a better understanding of methylation patterns in response to different treatment exposures.

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Identification of lymph node metastasis-related microRNAs in breast cancer using bioinformatics analysis

Abstract: Supplemental Digital Content is available in the text

Cited by 3 publications

References 27 publications

Integrated Omics Approach: Revealing the Mechanism of Auxenochlorella pyrenoidosa Protein Extract Replacing Fetal Bovine Serum for Fish Muscle Cell Culture

Integrated Omics Approach: Revealing the Mechanism of Auxenochlorella pyrenoidosa Protein Extract Replacing Fetal Bovine Serum for Fish Muscle Cell Culture

miRNAs as biomarkers breast cancer and their influence on tumor epigenetics

Detecting Blood Methylation Signatures in Response to Childhood Cancer Radiotherapy via Machine Learning Methods

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